Fig. 7 Vaccine-induced influenza-specific B cells are not maintained in peripheral blood. Vaccine-induced influenza-specific B cells are not maintained.

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Fig. 7 Vaccine-induced influenza-specific B cells are not maintained in peripheral blood. Vaccine-induced influenza-specific B cells are not maintained in peripheral blood. Responses in (A) antibody serum titers, (B) numbers of IgD−rHA+ B cells, (C) pie graphs of isotype distribution within each rHA+ population, (D) changes in isotype-specific class-switched rHA+ B cells, and (E) numbers of CD21hi and CD21lo influenza-specific B cells at baseline, d28, and >d350 (n = 9, 2015 cohort). Significance for changes from baseline was determined using Wilcoxon matched-pairs signed-rank test (*P < 0.05, **P < 0.005). (F to H) Numbers of (F) total IgD−rHA+ B cells and (G) CD21hi and (H) CD21loIgG+rHA+ B cells in individuals vaccinated in 2015 and 2016 (n = 8). Marios Koutsakos et al., Sci Transl Med 2018;10:eaan8405 Published by AAAS