CHAPTER 2 PRIMARY GLOMERULONEPHRITIS

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Presentation transcript:

CHAPTER 2 PRIMARY GLOMERULONEPHRITIS Sunita Bavanandan Lim Soo Kun Lee Han Wei

Table 2.1: Primary Glomerulonephritis, 2005-2010 4th MRRB report 2010, Malaysia

Table 2.2.2(a): Demographic characteristics for MCD, 2005-2010 n % Age (year) Mean (SD) 29.64 (12.86) Median (IQR) 25.00 (16.87) Min, max 15.00, 78.52 Gender Male 438 65.6 Female 230 34.4 Race Malay 405 60.6 Chinese 124 18.6 Indian 35 5.2 Others 104 15.6 4th MRRB report 2010, Malaysia

Figure 2.2.2(a): Demographic characteristics for MCD, 2005-2010 4th MRRB report 2010, Malaysia

Figure 2.2.2 (b): Age at time of biopsy (years) MCD, 2005-2010 Age group (years) 2005 2006 2007 2008 2009 2010 Total n % 15-<25 32 42.7 49 57.0 43 49.4 80 53.3 69 53.1 59 42.1 332 49.7 25-<35 20 26.7 23.3 17 19.5 35 28 21.5 30 21.4 150 22.5 35-<45 11 14.7 10 11.6 14 16.1 12 8.0 18 13.8 24 17.1 89 13.3 45-<55 4 4.7 6 6.9 8 6.2 21 15.0 61 9.1 55-<65 1 1.3 2 2.3 5 5.7 9 6.0 3 3.6 25 3.7 ≥65 1.2 3.1 0.7 1.6 75 100 86 87 130 140 668 4th MRRB report 2010, Malaysia

Figure 2.2.2 (b): Age at time of biopsy (years) MCD, 2005-2010 4th MRRB report 2010, Malaysia

Table 2.2.3 (a): Clinical presentation for MCD, 2005-2010 Clinical Presentations 2005 2006 2007 2008 2009 2010 Total n % Asymptomatic urine abnormality 3 4.0 9 10.5 12 13.8 19 12.7 16 12.3 20 14.3 79 11.8 Nephritic syndrome 2 2.7 3.5 4 4.6 5 3.3 3.1 2.9 22 Nephrotic syndrome 69 92.0 70 81.4 64 73.6 118 78.7 98 75.4 103 522 78.1 Nephritic-Nephrotic syndrome 1 1.3 2.3 3.4 6 7 5.4 6.4 28 4.2 Not available 0.0 3.8 17 2.5 75 100 86 87 150 130 140 668 4th MRRB report 2010, Malaysia

Figure 2.2.3 (a): Overall clinical presentation for MCD, 2005-2010 10 20 30 40 50 60 70 80 90 100 A. urine abnormality Nephritic Nephrotic - Not available Percentage (%) Clinical presentation Clinical presentation 2005 2010 4th MRRB report 2010, Malaysia

Table 2.2.3 (b): Presence of hypertension in MCD, 2005-2010 2006 2007 2008 2009 2010 Total n % Present 3 4.0 4 4.7 9 10.3 19 12.7 32 24.6 46 32.9 113 16.9 Absent 72 96.0 82 95.3 75 86.2 116 77.3 89 68.5 84 60.0 518 77.5 Missing 0.0 3.4 15 10.0 6.9 10 7.1 37 5.5 100 86 87 150 130 140 668 4th MRRB report 2010, Malaysia

Figure 2.2.3 (b): Presence of hypertension in MCD, 2005-2010 5 10 15 20 25 30 35 2005 2006 2007 2008 2009 2010 Percentage (%) Year Hypertension 4th MRRB report 2010, Malaysia

Table 2.2.3 (c): Renal function in MCD by year, 2005-2010 GFR (ml/min/1.73 m2) 2005 2006 2007 2008 2009 2010 Total n % <15 0.0 3 3.5 2 2.3 1.3 7 5.0 14 2.1 15 to < 30 1 1.2 5 5.7 4 2.7 5.4 25 3.7 30 to < 60 13 17.3 12 14.0 11 12.6 22 14.7 9 6.9 26 18.6 93 13.9 60 to < 90 19 25.3 17 19.8 28.7 27 18.0 28 21.5 18 12.9 134 20.1 > 90 36 48.0 48 55.8 42 48.3 86 57.3 77 59.2 67 47.9 356 53.3 Missing 6 8.0 5.8 6.0 15 10.7 46 75 100 87 150 130 140 668 *46 cases are missing on GFR, including 15 cases with GFR>200 (GFR range between 201 to 3349) 4th MRRB report 2010, Malaysia

Figure 2.2.3 (c): Impaired renal function in MCD by year, 2005-2010 5 10 15 20 25 30 35 2005 2006 2007 2008 2009 2010 Percentage (%) Year eGFR<60 ml/min 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.2.3.1 (a): Clinical presentation by age group for MCD, 2005-2010 Clinical Presentations 15-<25 25-<35 35-<45 45-<55 55-<65 ≥65 Total n % Asymptomatic urine abnormality 32 9.6 20 13.3 12 13.5 8 13.1 4 16.0 3 27.3 79 11.8 Nephritic syndrome 3.6 6 4.0 2 2.2 1 1.6 0.0 9.1 22 3.3 Nephrotic syndrome 264 79.5 114 76.0 70 78.7 49 80.3 19 54.5 522 78.1 Nephritic-Nephrotic syndrome 18 5.4 2.7 3.4 28 4.2 Not available 1.8 8.0 17 2.5 332 100 150 89 61 25 11 668 4th MRRB report 2010, Malaysia

Table 2.2.3.1 (b): Hypertension by age group for MCD, 2005-2010 15-<25 25-<35 35-<45 45-<55 55-<65 ≥65 Total n % Present 45 13.6 18 12.0 21 23.6 20 32.8 8 32.0 1 9.1 113 16.9 Absent 272 81.9 121 80.7 63 70.8 37 60.7 17 68.0 72.7 518 77.5 Not available/ Missing 15 4.5 11 7.3 5 5.6 4 6.6 0.0 2 18.2 5.5 332 100 150 89 61 25 668 4th MRRB report 2010, Malaysia

Figure 2.2.3.1 (b): Hypertension by age group for MCD, 2005-2010 5 10 15 20 25 30 35 - <25 <35 <45 45 <55 55 <65 ≥65 Percentage (%) Age group Hypertension 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.2.3.1 (c): Renal function at presentation by age group for MCD, 2005-2010 eGFR (ml/min/1.73m2) 15- <25 25- <35 35- <45 45- <55 55- <65 ≥65 Total n % <15 6 1.8 2 1.3 3 3.4 0.0 8.0 1 9.1 14 2.1 15-29 8 9.0 4 6.6 16.0 25 3.7 30-59 31 9.3 16 10.7 13 14.6 23 37.7 5 20.0 45.5 93 13.9 60-89 55 16.6 28 18.7 27 30.3 23.0 7 28.0 27.3 134 20.1 ≥90 207 62.3 92 61.3 32 36.0 18 29.5 24.0 356 53.3 Missing* 8.1 10 6.7 3.3 4.0 46 6.9 332 100 150 89 61 11 668 *Total of 46 cases are missing on GFR, including 15 cases with GFR>200 (GFR range between 201 to 3349) 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.2.3.1 (c): Impaired renal function at presentation by age group for MCD, 2005-2010 10 20 30 40 50 60 70 15 - <25 25 <35 35 <45 45 <55 55 <65 ≥65 Percentage (%) Age group eGFR<60ml/min 4th MRRB report 2010, Malaysia

Table 2.2.3.2 (a): Clinical presentation by gender for MCD, 2005-2010 Clinical Presentations Male Female n % Asymptomatic urine abnormality 41 9.4 38 16.5 Nephritic syndrome 14 3.2 8 3.5 Nephrotic syndrome 344 78.5 178 77.4 Nephritic-Nephrotic syndrome 28 6.4 0.0 Not available 11 2.5 6 2.6 Total 438 100 230 4th MRRB report 2010, Malaysia

Table 2.2.3.2 (b): Hypertension by gender for MCD, 2005-2010 Male Female n % Present 72 16.4 41 17.8 Absent 340 77.6 178 77.4 Not available/ Missing 26 5.9 11 4.8 Total 438 100 230 4th MRRB report 2010, Malaysia

Figure 2.2.3.2 (b): Hypertension by gender for MCD, 2005-2010 2 4 6 8 10 12 14 16 18 20 Male Female Percentage (%) Gender Hypertension 4th MRRB report 2010, Malaysia

Table 2.2.3.2 (c): Renal function by gender for MCD, 2005-2010 eGFR (ml/min/1.73m2) Male Female n % <15 11 2.5 3 1.3 15-29 18 4.1 7 3.0 30-59 64 14.6 29 12.6 60-89 83 18.9 51 22.2 ≥90 232 53.0 124 53.9 Missing* 30 6.8 16 7.0 Total 438 100 230 *Total of 46 cases are missing on GFR, including 15 cases with GFR>200 (GFR range between 201 to 3349) 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.2.3.2 (c): Impaired renal function by gender for MCD, 2005-2010 5 10 15 20 25 30 Male Female Percentage (%) Gender eGFR<60ml/min 4th MRRB report 2010, Malaysia

Table 2.3.2 (a): Demographic characteristics for FSGS, 2005-2010 n=598 % Age Mean (SD) 33.92 (14.36) Median (IQR) 30.67 (20.48) Min, max 15.00, 88.54 Gender Male 341 57.0 Female 257 43.0 Race Malay 378 63.2 Chinese 109 18.2 Indian 39 6.5 Others 72 12.0 4th MRRB report 2010, Malaysia

Figure 2.3.2(a): Demographic characteristics for FSGS, 2005-2010 Male, 57% Female, 43% Male, 57% Female, 43% Male, 57% Female, 43% Male, 57% Female, 43% Male, 57% Female, 43% Malay, 63% Chinese, 18% Indian, 7% Others, 12% 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.3.2 (b): Age group at time of biopsy (years) for FSGS, 2005-2010 Age group (years) 2005 2006 2007 2008 2009 2010 Total n % 15-<25 19 31.1 46 43.4 30 34.5 35 34.3 36 31.0 39 205 25-<35 17 27.9 23 21.7 28 32.2 31 30.4 29 25.0 22.2 156 26.1 35-<45 13 21.3 18 17.0 15 17.2 14 13.7 24 20.7 23.8 114 19.1 45-<55 8 13.1 9 8.5 10.3 12.7 10 8.6 13.5 66 11.0 55-<65 3 4.9 5 4.7 4 4.6 6 5.9 7 5.6 ≥65 1 1.6 1.1 2.9 6.0 4.0 22 3.7 61 100 106 87 102 116 126 598 4th MRRB report 2010, Malaysia

Figure 2.3.2 (b): Age at time of biopsy (years) for FSGS, 2005-2010 .01 .02 .03 .04 Density 20 40 60 80 100 Age at time of biopsy (years) 4th MRRB report 2010, Malaysia

Table 2.3.3 (a): Clinical presentation for FSGS, 2005-2010 Clinical Presentations 2005 2006 2007 2008 2009 2010 Total n % Asymptomatic urine abnormality 10 16.4 19 17.9 17 19.5 29 28.4 35 30.2 33 26.2 143 23.9 Nephritic syndrome 4 6.6 5 4.7 6 6.9 5.9 3 2.6 7 5.6 31 5.2 Nephrotic syndrome 43 70.5 76 71.7 55 63.2 57 55.9 64 55.2 67 53.2 362 60.5 Nephritic-Nephrotic syndrome 1 1.6 0.0 3.9 8.6 12 9.5 5.5 Not available/ Missing 4.9 5.7 3.4 4.8 61 100 106 87 102 116 126 598 4th MRRB report 2010, Malaysia

Figure 2.3.3 (a): Overall clinical presentation for FSGS, 2005-2010 10 20 30 40 50 60 70 80 A. urine abnormality Nephritic Nephrotic - NA/ Missing Percentage (%) Clinical presentation Clinical presentation 2005 2010 4th MRRB report 2010, Malaysia

Table 2.3.3 (b): Hypertension in FSGS, 2005-2010 2006 2007 2008 2009 2010 Total n % Present 4 6.6 3.8 15 17.2 38 37.3 61 56.0 59 48.4 181 30.8 Absent 55 90.2 102 96.2 70 80.5 54 52.9 40 36.7 45 36.9 366 62.4 Not available/Missing 2 3.3 0.0 2.3 10 9.8 8 7.3 18 14.8 6.8 100 106 87 109 122 587 4th MRRB report 2010, Malaysia

Figure 2.3.3 (b): Hypertension in FSGS, 2005-2010 10 20 30 40 50 60 2005 2006 2007 2008 2009 2010 Percentage (%) Year Hypertension 4th MRRB report 2010, Malaysia

Table 2.3.3 (c): Renal function in FSGS by year, 2005-2010 GFR (ml/min/1.73m2) 2005 2006 2007 2008 2009 2010 Total n % <15 3 4.9 2 1.9 2.3 7 6.9 6.0 10 7.9 31 5.2 15-29 8 13.1 14 13.2 9.2 9 8.8 22 19.0 17 13.5 78 13.0 30-59 19 31.1 16.0 25.3 30.4 30 25.9 24 143 23.9 60-89 11.5 27 25.5 25 28.7 16.7 26 22.4 126 21.1 ≥90 36.1 40 37.7 32 31.4 42 33.3 183 30.6 Missing* 3.3 6 5.7 5 5.9 7.8 7.1 37 6.2 61 100 106 87 102 116 598 *Total of 37 cases are missing on GFR, including 9 cases with GFR>200 (GFR range between 205 to 511) 4th MRRB report 2010, Malaysia

Figure 2.3.3 (c): Impaired renal function in FSGS by year, 2005-2010 10 20 30 40 50 60 2005 2006 2007 2008 2009 2010 Percentage (%) Year eGFR<60ml/min 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.3.3.1 (a): Clinical presentation by age group for FSGS, 2005-2010 Age group (years) 15- <25 25-<35 35-<45 45-<55 55-<65 ≥65 Total n % Asymptomatic urine abnormality 29 14.1 55 35.3 32 28.1 16 24.2 8 22.9 3 14.3 143 23.9 Nephritic syndrome 11 5.4 7.1 5 4.4 1 1.5 8.6 0.0 31 5.2 Nephrotic syndrome 152 74.1 73 46.8 61 53.5 38 57.6 24 68.6 14 66.7 362 60.5 Nephritic-Nephrotic syndrome 3.9 9 5.8 7.0 6 9.1 2 9.5 33 5.5 Not available/ Missing 2.4 5.1 7.6 4.8 205 100 156 114 66 35 21 598 4th MRRB report 2010, Malaysia

Table 2.3.3.1 (b): Hypertension by age group for FSGS, 2005-2010 15- <25 25-<35 35-<45 45-<55 55-<65 ≥65 Total n % Present 39 19.0 41 26.3 43 37.7 31 47.0 16 45.7 11 50.0 181 30.3 Absent 148 72.2 99 63.5 63 55.3 15 42.9 10 45.5 366 61.2 Missing 18 8.8 10.3 8 7.0 4 6.1 11.4 1 4.5 51 8.5 205 100 156 114 66 35 22 598 4th MRRB report 2010, Malaysia

Figure 2.3.3.1 (b): Hypertension by age group for FSGS, 2005-2010 10 20 30 40 50 60 15 - <25 25 <35 35 <45 45 <55 55 <65 ≥65 Percentage (%) Age group Hypertension 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.3.3.1 (c): Renal function at presentation by age group for FSGS, 2005-2010 GFR (ml/min/1.73m2) 15- <25 25- <35 35- <45 45- <55 55- <65 ≥65 Total n % <15 8 3.9 6 3.8 5.3 5 7.6 3 8.6 13.6 31 5.2 15-29 11 5.4 20 12.8 19 16.7 22.9 9 40.9 78 13.0 30-59 43 21.0 36 23.1 28 24.6 22 33.3 25.7 22.7 143 23.9 60-89 32 15.6 34 21.8 30 26.3 16 24.2 10 28.6 4 18.2 126 21.1 ≥90 93 45.4 52 27 23.7 7 10.6 11.4 0.0 183 30.6 Missing* 18 8.8 5.1 3.5 1 2.9 4.5 37 6.2 205 100 156 114 66 35 598 *Total of 37 cases are missing on GFR, including 9 cases with GFR>200 (GFR range between 205 to 511) 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.3.3.1 (c): Renal function at presentation by age group for FSGS, 2005-2010 10 20 30 40 50 60 70 80 90 15 - <25 25 <35 35 <45 45 <55 55 <65 ≥65 Percentage (%) Age group eGFR<60ml/min 4th MRRB report 2010, Malaysia

Table 2.3.3.2 (a): Clinical presentation by gender for FSGS, 2005-2010 Clinical Presentations Male Female Total n % Asymptomatic urine abnormality 62 18.2 81 31.5 143 23.9 Nephritic syndrome 17 5.0 14 5.4 31 5.2 Nephrotic syndrome 226 66.3 136 52.9 362 60.5 Nephritic-Nephrotic syndrome 21 6.2 12 4.7 33 5.5 Not available/ Missing 15 4.4 29 4.8 341 100 257 598 4th MRRB report 2010, Malaysia

Table 2.3.3.2 (b): Hypertension by gender in FSGS, 2005-2010 Male Female Total n % Present 102 29.9 79 30.7 181 30.3 Absent 211 61.9 155 60.3 366 61.2 Missing 28 8.2 23 8.9 51 8.5 341 100 257 598 4th MRRB report 2010, Malaysia

Figure 2.3.3.2 (b): Hypertension by gender in FSGS, 2005-2010 5 10 15 20 25 30 35 40 Male Female Percentage (%) Gender Hypertension 4th MRRB report 2010, Malaysia

Table 2.3.3.2 (c): Renal function by gender for FSGS, 2005-2010 GFR (ml/min/1.73m2) Male Female Total n % <15 14 4.1 17 6.6 31 5.2 15-29 44 12.9 34 13.2 78 13.0 30-59 80 23.5 63 24.5 143 23.9 60-89 73 21.4 53 20.6 126 21.1 ≥90 109 32.0 74 28.8 183 30.6 Missing* 21 6.2 16 37 341 100 257 598 *Total of 37 cases are missing on GFR, including 9 cases with GFR>200 (GFR range between 205 to 511) 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.3.3.2 (c): Impaired renal function by gender in FSGS, 2005-2010 5 10 15 20 25 30 35 40 45 50 Male Female Percentage (%) Gender eGFR<60ml/min 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.4.2(a): Demographic characteristics of patients with IgA nephropathy, 2005-2010 Demographic Characteristics n=421 % Age (years) Mean (SD) 33.16 (12.27) Median (IQR) 31.44 (16.72) Min, max 15.02, 85.25 Gender Male 193 45.8 Female 228 54.2 Race Malay 225 53.4 Chinese 117 27.8 Indian 32 7.6 Others 47 11.2 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.4.2(a): Demographic characteristics of patients with IgA nephropathy, 2005-2010 Male, 46% Female, 54% Malay, 53% Chinese, 28% Indian, 8% Others, 11% 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.4.2 (b): Age group at time of biopsy (years) for IgA nephropathy, 2005-2010 Age group (years) 2005 2006 2007 2008 2009 2010 Total n % 15-<25 5 16.1 15 29.4 28.3 29 31.9 35 38.9 31 29.5 130 30.9 25-<35 10 32.3 14 27.5 21 39.6 23 25.3 25.6 34 32.4 125 29.7 35-<45 11 21.6 8 15.1 22 24.4 19 18.1 93 22.1 45-<55 2 6.5 15.7 7 13.2 11.0 7.8 13 12.4 47 11.2 55-<65 3 9.7 3.9 3.8 3.3 2.2 6.7 4.5 ≥65 1 3.2 2.0 0.0 1.1 1.0 1.7 100 51 53 91 90 105 421 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.4.2 (b): Age at time of biopsy (years) for IgA nephropathy, 2005-2010 .01 .02 .03 .04 Density 20 40 60 80 Age at time of biopsy (years) 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.4.3 (a): Overall clinical presentation for IgA nephropathy, 2005-2010 Clinical Presentations 2005 2006 2007 2008 2009 2010 Total n % Asymptomatic urine abnormality 19 61.3 20 39.2 28 52.8 58 63.7 39 43.3 51 48.6 215 51.1 Nephritic syndrome 1 3.2 3 5.9 4 7.5 8 8.8 6 6.7 10 9.5 32 7.6 Nephrotic syndrome 25.8 16 31.4 11 20.8 21 23.1 22 24.4 27 25.7 105 24.9 Nephritic-Nephrotic syndrome 0.0 3.3 12 13.3 Not available 9.7 9 17.6 11.3 1.1 12.2 7 37 31 100 53 91 90 421 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.4.3 (a): Overall clinical presentation for IgA nephropathy, 2005-2010 10 20 30 40 50 60 70 A. urine abnormality Nephritic Nephrotic - Not available Percentage (%) Clinical presentation Clinical presentation 2005 2010 4th MRRB report 2010, Malaysia

Table 2.4.3 (b): Hypertension in IgA nephropathy, 2005-2010 2006 2007 2008 2009 2010 Total n % Present 4 12.9 7 13.7 20 37.7 39 42.9 47 52.2 65 61.9 182 43.2 Absent 26 83.9 44 86.3 31 58.5 43 47.3 34 37.8 33 31.4 211 50.1 Not available/ Missing 1 3.2 0.0 2 3.8 9 9.9 10.0 6.7 28 100 51 53 91 90 105 421 4th MRRB report 2010, Malaysia

Table 2.4.3(c): Renal function in IgA nephropathy, 2005-2010 GFR (ml/min/1.73m2) 2005 2006 2007 2008 2009 2010 Total n % N <15 0.0 6 11.8 7 13.2 7.7 11 12.2 25 23.8 56 13.3 15-29 4 12.9 13.7 5 9.4 8 8.8 6.7 12 11.4 42 10.0 30-59 9 29.0 15 29.4 13 24.5 24 26.4 22 24.4 21.0 105 24.9 60-89 41.9 15.1 19 20.9 21.1 16 15.2 90 21.4 ≥90 16.1 18 34.0 27.5 26 28.9 22.9 104 24.7 Missing* 2 3.9 3.8 5.7 31 100 51 53 91 421 *Total of 24 cases are missing on GFR 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.4.3.1 (a): Clinical presentation by age group for IgA nephropathy, 2005-2010 Age group (years) 15- <25 25-<35 35-<45 45-<55 55-<65 ≥65 Total n % Asymptomatic urine abnormality 54 41.5 68 54.4 53 57.0 23 48.9 15 78.9 2 28.6 215 51.1 Nephritic syndrome 17 13.1 12 9.6 2.2 1 2.1 0.0 32 7.6 Nephrotic syndrome 39 30.0 18.4 21 22.6 36.2 10.5 3 42.9 105 24.9 Nephritic-Nephrotic syndrome 9.2 9 7.2 8 8.6 4.3 5.3 Missing 6.2 13 10.4 9.7 4 8.5 37 8.8 130 100 125 93 47 19 7 421 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.4.3.1 (b): Hypertension by age group for IgA nephropathy, 2005-2010 Hypertension 15- <25 25-<35 35-<45 45-<55 55-<65 ≥65 Total n % Present 51 39.2 47 37.6 45 48.4 26 55.3 8 42.1 5 71.4 182 43.2 Absent 71 54.6 64 51.2 44 47.3 20 42.6 10 52.6 2 28.6 211 50.1 Missing 6.2 14 11.2 4 4.3 1 2.1 5.3 0.0 28 6.7 130 100 125 93 19 7 421 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.4.3.1 (b): Hypertension by age group for IgA nephropathy, 2005-2010 10 20 30 40 50 60 70 80 15 - <25 25 <35 35 <45 45 <55 55 <65 ≥65 Percentage (%) Age group Hypertension 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.4.3.1 (c): Renal function at presentation by age group for IgA nephropathy, 2005-2010 GFR (ml/min/1.73m2) 15- <25 25- <35 35- <45 45- <55 55- <65 ≥65 Total n % <15 12 9.2 14 11.2 13 14.0 25.5 4 21.1 1 14.3 56 13.3 15-29 10.0 10.4 6 6.5 8.5 3 15.8 42.9 42 30-59 28 21.5 34 27.2 25 26.9 29.8 2 10.5 28.6 105 24.9 60-89 17 13.1 30 24.0 31.6 0.0 90 21.4 ≥90 50 38.5 18.3 104 24.7 Missing* 10 7.7 3.2 7 7.5 2.1 24 5.7 130 100 125 93 47 19 421 *Total of 24 cases are missing on GFR 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.4.3.1 (c): Impaired renal function at presentation by age group for IgA nephropathy, 2005-2009 10 20 30 40 50 60 70 80 90 100 15 - <25 25 <35 35 <45 45 <55 55 <65 ≥65 Percentage (%) Age group eGFR<60ml/min 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.4.3.2 (a): Clinical presentation by gender for IgA nephropathy, 2005-2010 Clinical Presentations Male Female Total n % Asymptomatic urine abnormality 91 47.2 124 54.4 215 51.1 Nephritic syndrome 16 8.3 7.0 32 7.6 Nephrotic syndrome 53 27.5 52 22.8 105 24.9 Nephritic-Nephrotic syndrome 15 7.8 17 7.5 Not available 18 9.3 19 37 8.8 193 100 228 421 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.4.3.2 (b): Hypertension by gender for IgA nephropathy, 2005-2010 Hypertension Male Female Total n % Present 91 47.2 39.9 182 43.2 Absent 92 47.7 119 52.2 211 50.1 Missing 10 5.2 18 7.9 28 6.7 193 100 228 421 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.4.3.2 (b): Hypertension by gender for IgA nephropathy, 2005-2010 10 20 30 40 50 60 Male Female Percentage (%) Gender Hypertension 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.4.3.2 (c): Renal function by gender for IgA nephropathy, 2005-2010 GFR (ml/min/1.73m2) Male Female Total n % <15 25 13.0 31 13.6 56 13.3 15-29 27 14.0 15 6.6 42 10.0 30-59 47 24.4 58 25.4 105 24.9 60-89 33 17.1 57 25.0 90 21.4 ≥90 49 55 24.1 104 24.7 Missing* 12 6.2 5.3 24 5.7 193 100 228 421 *Total of 24 cases are missing on GFR 4th MRRB report 2010, Malaysia

Figure 2.4.3.2 (c): Impaired renal function by gender in 2005-2010 10 20 30 40 50 60 Male Female Percentage (%) Gender eGFR<60ml/min 4th MRRB report 2010, Malaysia

Table 2.5.2 (a): Demographic characteristics for IMN, 2005-2010 % Age (years) Mean (SD) 44.81 (15.17) Median (IQR) 44.07 (22.55) Min, max 15.11, 84.35 Gender Male 100 53.2 Female 88 46.8 Race Malay 79 42.0 Chinese 70 37.2 Indian 16 8.5 Other 23 12.2 4th MRRB report 2010, Malaysia

Figure 2.5.2 (a): Demographic characteristics for IMN, 2005-2010 Malay, 42% Chinese, 37% Indian, 9% Other, 12% Male, 53% Female, 47% 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.5.2 (b): Age group at time of biopsy (years) for IMN, 2005-2010 Age group (years) 2005 2006 2007 2008 2009 2010 Total n % 15-<25 3 13.0 1 3.0 2 6.1 5 13.5 4 16.0 20 10.6 25-<35 17.4 8 24.2 21.6 12.0 36 19.1 35-<45 15.2 6 18.2 12 32.4 39 20.7 45-<55 7 21.2 10 30.3 9 36.0 45 23.9 55-<65 9.1 16.2 8.0 8.1 28 14.9 ≥ 65 21.7 12.1 5.4 10.8 23 100 33 37 25 188 4th MRRB report 2010, Malaysia

Figure 2.5.2 (b): Age at time of biopsy (years) for IMN, 2005-2010 .01 .02 .03 Density 20 40 60 80 Age at time of biopsy (years) 4th MRRB report 2010, Malaysia

Table 2.5.3 (a): Overall clinical presentation for IMN, 2005-2010 Clinical Presentations 2005 2006 2007 2008 2009 2010 Total n % Asymptomatic urine abnormality 1 4.3 8 24.2 9 27.3 10 27.0 11 44.0 6 16.2 45 23.9 Nephritic syndrome 3.0 0.0 2.7 3 1.6 Nephrotic syndrome 20 87.0 21 63.6 23 69.7 62.2 13 52.0 29 78.4 129 68.6 Nephritic-Nephrotic syndrome 2 5.4 4.0 3.2 Not available 6.1 5 100 33 37 25 188 4th MRRB report 2010, Malaysia

Figure 2.5.3 (a): Clinical presentation for IMN, 2005-2010 10 20 30 40 50 60 70 80 A. urine abnormality Nephritic Nephrotic - Not available Percentage (%) Clinical presentation Clinical presentation 2005 2010 4th MRRB report 2010, Malaysia

Table 2.5.3 (b): Hypertension in IMN, 2005-2010 2006 2007 2008 2009 2010 Total n % Present 6 26.1 3 9.1 2 6.1 15 40.5 8 32.0 14 37.8 48 25.5 Absent 17 73.9 30 90.9 19 51.4 60.0 45.9 128 68.1 Not available 0.0 1 3.0 8.1 8.0 16.2 12 6.4 23 100 33 37 25 188 4th MRRB report 2010, Malaysia

Table 2.5.3(c): Renal function in IMN, 2005-2010 GFR (ml/min/1.73m2) 2005 2006 2007 2008 2009 2010 Total n % <15 0.0 1 3.0 2 6.1 4.0 4 2.1 15-29 3 13.0 9.1 5.4 8.1 13 6.9 30-59 17.4 12 36.4 8 24.2 9 24.3 12.0 6 16.2 42 22.3 60-89 26.1 14 37.8 11 44.0 7 18.9 54 28.7 ≥90 10 43.5 30.3 27.0 32.0 19 51.4 65 34.6 Missing* 8.0 5.3 23 100 33 37 25 188 *Total of 10 cases are missing on GFR, including 4 cases with GFR>200 (GFR range between 207 to 1312) 4th MRRB report 2010, Malaysia

Figure 2.5.3(c): Renal function in IMN, 2005-2010 10 20 30 40 50 60 2005 2006 2007 2008 2009 2010 Percentage (%) Year eGFR<60ml/min 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.5.3.1(a): Clinical presentation by age group for IMN, 2005-2010 Age group (years) 15- <25 25-<35 35-<45 45-<55 55-<65 ≥65 Total n % Asymptomatic urine abnormality 5 25.0 8 22.2 20.5 11 24.4 12 42.9 1 5.0 45 23.9 Nephritic syndrome 0.0 2 4.4 3.6 3 1.6 Nephrotic syndrome 60.0 26 72.2 28 71.8 30 66.7 14 50.0 19 95.0 129 68.6 Nephritic-Nephrotic syndrome 10.0 5.1 6 3.2 Not available 5.6 2.6 2.7 20 100 36 39 188 4th MRRB report 2010, Malaysia

Table 2.5.3.1(b): Hypertension by age group for IMN, 2005-2010 15- <25 25-<35 35-<45 45-<55 55-<65 >=65 Total n % Present 7 35.0 4 11.1 10 25.6 8 17.8 11 39.3 40.0 48 25.5 Absent 12 60.0 29 80.6 26 66.7 34 75.6 15 53.6 128 68.1 Not available 1 5.0 3 8.3 7.7 6.7 2 7.1 0.0 6.4 20 100 36 39 45 28 188 4th MRRB report 2010, Malaysia

Figure 2.5.3.1 (b): Hypertension by age group for IMN, 2005-2010 5 10 15 20 25 30 35 40 45 - <25 <35 <45 <55 55 <65 ≥65 Percentage (%) Age group Hypertension 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Table 2.5.3.1 (c): Renal function at presentation by age group for IMN, 2005-2010 eGFR (ml/min/1.73m2) 15- <25 25- <35 35- <45 45- <55 55- <65 ≥ 65 Total n % <15 0.0 1 2.8 2.6 2.2 3.6 4 2.1 15-29 5.0 2 5.6 3 6.7 10.7 15.0 13 6.9 30-59 5 13.9 6 15.4 9 20.0 32.1 12 60.0 42 22.3 60-89 25.0 30.8 19 42.2 10 35.7 54 28.7 ≥90 17 85.0 47.2 43.6 11 24.4 7.1 65 34.6 Missing* 5.1 4.4 5.3 20 100 36 39 45 28 188 *Total of 10 cases are missing on GFR, including 4 cases with GFR>200 (GFR range between 207 to 1312) 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.5.3.1 (c): Renal function at presentation by age group for IMN, 2005-2010 10 20 30 40 50 60 70 80 15 - <25 25 <35 35 <45 45 <55 55 <65 ≥65 Percentage (%) Age group eGFR<60ml/min 4th MRRB report 2010, Malaysia

Table 2.5.3.2 (a): Clinical presentation by gender for IMN, 2005-2010 Clinical Presentations Male Female Total n % Asymptomatic urine abnormality 24 24.0 21 23.9 45 Nephritic syndrome 2 2.0 1 1.1 3 1.6 Nephrotic syndrome 68 68.0 61 69.3 129 68.6 Nephritic-Nephrotic syndrome 3.0 3.4 6 3.2 Not available 2.3 5 2.7 100 88 188 4th MRRB report 2010, Malaysia

Table 2.5.3.2 (b): Hypertension by gender for IMN, 2005-2010 Male Female Total n % Present 27 27.0 21 23.9 48 25.5 Absent 68 68.0 60 68.2 128 68.1 Missing 5 5.0 7 8.0 12 6.4 100 88 188 4th MRRB report 2010, Malaysia

Figure 2.5.3.2 (b): Hypertension by gender for IMN, 2005-2010 5 10 15 20 25 30 35 Male Female Percentage (%) Gender Hypertension 4th MRRB report 2010, Malaysia

Table 2.5.3.2 (c): Renal function by gender for IMN, 2005-2010 GFR (ml/min/1.73m2) Male Female Total n % <15 2 2.0 2.3 4 2.1 15-29 9 9.0 4.5 13 6.9 30-59 26 26.0 16 18.2 42 22.3 60-89 34 34.0 20 22.7 54 28.7 ≥90 25 25.0 40 45.5 65 34.6 Missing* 4.0 6 6.8 10 5.3 100 88 188 *Total of 10 cases are missing on GFR, including 4 cases with GFR>200 (GFR range between 207 to 1312) 4th MRRB report 2010, Malaysia

4th MRRB report 2010, Malaysia Figure 2.5.3.2 (c): Impaired renal function by gender for IMN, 2005-2010 5 10 15 20 25 30 35 40 45 Male Female Percentage (%) Gender eGFR<60ml/min 4th MRRB report 2010, Malaysia