Longitudinal evaluation of T1ρ and T2 spatial distribution in osteoarthritic and healthy medial knee cartilage J. Schooler, D. Kumar, L. Nardo, C. McCulloch,

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Longitudinal evaluation of T1ρ and T2 spatial distribution in osteoarthritic and healthy medial knee cartilage J. Schooler, D. Kumar, L. Nardo, C. McCulloch, X. Li, T.M. Link, S. Majumdar Osteoarthritis and Cartilage Volume 22, Issue 1, Pages 51-62 (January 2014) DOI: 10.1016/j.joca.2013.10.014 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Representative sagittal SPGR images with T1ρ relaxation times superimposed on articular cartilage as a color overlay of a healthy control at (A) baseline and (B) at the 2-year follow-up. OA patient at (C) baseline and (D) at the 2-year follow-up. Qualitative OA spatial heterogeneity increases are visible near the anterior portion of the MF/MT. Color scale (right) measured in milliseconds. Osteoarthritis and Cartilage 2014 22, 51-62DOI: (10.1016/j.joca.2013.10.014) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Sagittal T2-weighted FSE images displaying (A) a MF osteoarthritic partial-thickness lesion (arrow) associated with underlying bone marrow edema mWORMS grade 2 (0.7 mm) and (B) a healthy control with intact cartilage. Osteoarthritis and Cartilage 2014 22, 51-62DOI: (10.1016/j.joca.2013.10.014) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Global mean T1ρ and T2 relaxation times (A and B) and mean articular layer T2 relaxation times (C) in the MF. Single asterisk indicates P < 0.05, double asterisk indicates P < 0.01, and cross indicates P = 0.07–0.051 (approaching significance). Longitudinal significance between the groups is denoted above the horizontal bracket. Osteoarthritis and Cartilage 2014 22, 51-62DOI: (10.1016/j.joca.2013.10.014) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Mean T1ρ entropy (A and B) in the MT. Single asterisk indicates P < 0.05, double asterisk indicates P < 0.01. Longitudinal significance between the groups is denoted above the horizontal bracket. Osteoarthritis and Cartilage 2014 22, 51-62DOI: (10.1016/j.joca.2013.10.014) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Global mean and articular T2 relaxation times (A and B) and mean T2 entropy in the MT. Single asterisk indicates P < 0.05, double asterisk indicates P < 0.01, and cross indicates P = 0.07–0.051 (approaching significance). Longitudinal significance between the groups is denoted above the horizontal bracket. Osteoarthritis and Cartilage 2014 22, 51-62DOI: (10.1016/j.joca.2013.10.014) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions