Long-term survival of cardiac xenografts in fully xenogeneic (mouse → rat) bone marrow chimeras Muhammad M Mohiuddin, MD, Yong Qin, MD, Xiaohua Qian,

Slides:

Advertisements

Similar presentations

Aortic Valve Replacement With Patch Enlargement of the Aortic Annulus

Advertisements

Non–Small Cell Lung Cancer at the Extremes of Age: Impact on Diagnosis and Treatment William C Nugent, MD, Mark T Edney, BA, Paul G Hammerness, BA, Bradley.

David D. Yuh, MD, Kimberly L. Gandy, MD, Bruce A

Survival Benefit of Aortic Valve Replacement in Patients With Severe Aortic Stenosis With Low Ejection Fraction And Low Gradient With Normal Ejection.

Early postoperative outcome and medium-term survival in 540 diabetic and 2239 nondiabetic patients undergoing coronary artery bypass grafting Zoltán.

Definitive or Preoperative Chemoradiation Therapy for Esophageal Cancer: Patterns of Care and Survival Outcomes Meng S. Shao, MD, Andrew T. Wong, MD,

Improved clinical outcomes in patients undergoing coronary artery bypass grafting with coronary endarterectomy Oz M Shapira, MD, Gabriel Akopian, Ali.

Leena Khaitan, MD, Francis P Sutter, Scott M Goldman, MD

Yumi Matsuzaki, Kentaro Kinjo, Richard C Mulligan, Hideyuki Okano

Outcomes of Reintervention on the Autograft After Ross Procedure

C-Reactive Protein Predicts Acute Kidney Injury and Death After Coronary Artery Bypass Grafting Seung Seok Han, MD, PhD, Dong Ki Kim, MD, PhD, Sejoong.

Effects of donor bone marrow infusion in clinical lung transplantation

Lisa M. Brown, MD, MAS, David T. Cooke, MD, Elizabeth A. David, MD

Monocyte Fc gamma receptor expression in patients undergoing coronary artery bypass grafting Demetrios C Stefanou, FRCS, George Asimakopoulos, FRCS,

Long-Term Consequences of Postoperative Heart Failure After Surgery for Aortic Stenosis Compared With Coronary Surgery Farkas B. Vánky, MD, PhD, Erik.

Use of EAS to define TCR-Vb3- and TCR-Cb1-expressing T cells

Elevation of Antidonor Immunoglobulin M Levels Precedes Acute Lung Transplant Rejection Kentaroh Miyoshi, MD, Yoshifumi Sano, MD, Masaomi Yamane, MD,

Creation of Chimeric Hearts: A Tool for Testing the “Passenger Leukocyte” Hypothesis Simon D Eiref, Wei Zhang, Sicco H Popma, Lisa J Shah, Jonni S Moore,

ABO-Identical Blood Group Matching Has No Survival Benefit for AB Heart Transplant Recipients Henrik Bergenfeldt, MD, Peter Höglund, MD, PhD, Bodil Andersson,

The Impact of Peripheral Vascular Disease on Long-Term Survival After Coronary Artery Bypass Graft Surgery Danny Chu, MD, Faisal G. Bakaeen, MD, Xing.

Operative Results and Outcomes in Children With Shone's Anomaly

Total Arch Replacement With Stented Elephant Trunk Technique for Acute Type B Aortic Dissection Involving the Aortic Arch Hai-Peng Zhao, MD, Jun-Ming.

Murine Bone Marrow Stromal Progenitor Cells Elicit an In Vivo Cellular and Humoral Alloimmune Response Andrea T. Badillo, Kirstin J. Beggs, Elisabeth.

Lung Cancer Surgery in Patients With Liver Cirrhosis

T Cell and B Cell Immunity can be Reconstituted with Mismatched Hematopoietic Stem Cell Transplantation Without Alkylator Therapy in Artemis-Deficient.

Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery John L Francis, PhD, George J Palmer, MD, Rebecca Moroose,

Genetically engineered pigs and target-specific immunomodulation provide significant graft survival and hope for clinical cardiac xenotransplantation

Mixed hematopoietic chimerism induces long-term tolerance to cardiac allografts in miniature swine Margaret L Schwarze, MD, Matthew T Menard, MD, Yasushi.

Flow cytometric analysis of a localized malignant mesothelioma

Impact of Blood Product Transfusion on Short and Long-Term Survival After Cardiac Surgery: More Evidence Balu Bhaskar, MD, FCICM, Joel Dulhunty, PhD,

Bartosz Rylski, MD, Nimesh D. Desai, MD, PhD, Joseph E

One-stage coronary and abdominal aortic operation with or without cardiopulmonary bypass: early and midterm follow-up Raimondo Ascione, MD, Gabriele.

Non–Small Cell Lung Cancer at the Extremes of Age: Impact on Diagnosis and Treatment William C Nugent, MD, Mark T Edney, BA, Paul G Hammerness, BA, Bradley.

Outcomes after resection of giant emphysematous bullae

Effect of blood transfusion on long-term survival after cardiac operation Milo C Engoren, MD, Robert H Habib, PhD, Anoar Zacharias, MD, Thomas A Schwann,

Cardiac Arrhythmia After Open Thoracoabdominal Aortic Aneurysm Repair

Cytokines and cytotoxic pathways in engraftment resistance to purified allogeneic hematopoietic stem cells Christian Scheffold, Yolanda C. Scheffold,

Cardiac Operations in Patients 90 Years of Age and Older

Mechanisms of tolerance induction and prevention of cardiac allograft vasculopathy in miniature swine: The effect of augmentation of donor antigen load

Lack of correlation between an assay used to determine early marrow allograft rejection and long-term chimerism after murine allogeneic bone marrow transplantation:

Long-Term Survival and Freedom From Reoperation After Placement of a Pulmonary Xenograft Valved Conduit George M. Alfieris, MD, Michael F. Swartz, PhD,

Sarah C. Huen, MD, Chirag R. Parikh, MD, PhD

William M. Whited, MD, Paul Henley, BS, Erin M

Role of anti-Galα1,3Gal and anti–platelet antibodies in hyperacute rejection of pig lung by human blood Steffen Pfeiffer, MD, George L Zorn, MD, Sean.

Interleukin-6 and “complex” cardiac myxoma

James S Allan, Joseph K Choo, Liana Vesga, J

Importance of thymus to maintain operational tolerance to fully allogeneic cardiac grafts Masanori Niimi, MD, PhD, Nozomu Shirasugi, MD, Yosifumi Ikeda,

SOCS1 Deficiency Causes a Lymphocyte-Dependent Perinatal Lethality

Luisa Lunardon, MD, Aimee S. Payne, MD, PhD

Survival After Isolated Coronary Artery Bypass Grafting in Patients With Severe Left Ventricular Dysfunction Waleed A. Ahmed, MD, Phillip J. Tully, BHSc(Hons),

Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts Bryce D Beseth, MD, Robert B Cameron, MD, Pamela Leland,

Trends in Patient Characteristics and Outcomes of Coronary Artery Bypass Grafting in the 2000 to 2012 Medicare Population Christian McNeely, MD, Stephen.

Prolonged Intensive Care Unit Stay in Cardiac Surgery: Risk Factors and Long-Term- Survival Ortrud Vargas Hein, MD, Jürgen Birnbaum, MD, Klaus Wernecke,

Total Arterial Off-Pump Coronary Surgery: Time to Change Our Habits?

Invited Commentary The Annals of Thoracic Surgery

Aortic valve replacement: comparison of late survival between autografts and homografts Christopher J Knott-Craig, MD, Ronald C Elkins, MD, KathyLee.

Completeness of Revascularization and Survival Among Octogenarians With Triple- Vessel Disease Siamak Mohammadi, MD, Dimitri Kalavrouziotis, MD, Francois.

Pulsed Doppler intraoperative flow assessment and midterm coronary graft patency Yves A.G Louagie, MD, PhD, Carlos E Brockmann, MD, Jacques Jamart, MD,

The future of cardiac surgery training: A survival guide

Neal S Goldstein, MD The Annals of Thoracic Surgery

Comparison of open subxiphoid pericardial drainage with percutaneous catheter drainage for symptomatic pericardial effusion Jerome M McDonald, MD, Bryan.

Bilateral internal thoracic artery grafting in Insulin-Treated diabetics: should it be avoided? Oren Lev-Ran, MD, Rephael Mohr, MD, Kramer Amir, MD,

Bilateral Internal Thoracic Artery Grafts in Hemodialysis: A Single-Center Propensity Score Analysis Yoshinori Nakahara, MD, Shigehiko Yoshida, MD, Takeyuki.

Isolated tumor cells in bone marrow predict reduced survival in node-negative non-small cell lung cancer Bernward Passlick, MD, Boris Kubuschok, MD,

Patient-Prosthesis Mismatch After Mitral Valve Replacement: A Propensity Score Analysis Ho Young Hwang, MD, PhD, Yong Han Kim, MD, Kyung-Hwan Kim, MD,

Dumbor L. Ngaage, MD, FRCS (C-Th), Michael E. Cowen, FRCS

Phillip S. Naimo, BS, Matthew S

Self-Management of Oral Anticoagulation Therapy Improves Long-Term Survival in Patients With Mechanical Heart Valve Replacement Heinrich Koertke, MD,

Left Ventricular End-Diastolic Pressure Predicts Survival in Coronary Artery Bypass Graft Surgery Patients Jeevan Nagendran, MD, PhD, Colleen M. Norris,

Hari Padmanabhan, MRCP, Matthew J. Brookes, PhD, Alan M

Presentation transcript:

Long-term survival of cardiac xenografts in fully xenogeneic (mouse → rat) bone marrow chimeras Muhammad M Mohiuddin, MD, Yong Qin, MD, Xiaohua Qian, MD, PhD, Yuru Meng, MD, Verdi J DiSesa, MD The Annals of Thoracic Surgery Volume 72, Issue 3, Pages 740-745 (September 2001) DOI: 10.1016/S0003-4975(01)02811-9

Fig 1 Flow cytometric analysis of peripheral blood lymphocytes of one representative chimeric rat 30 days after reconstitution with donor marrow showing complete replacement with mouse donor cells: peripheral blood lymphocytes were stained by (A) FITC labeled antirat MHC Class I antibody (RT1AAVL) and (B) PE labeled mouse anti-Class I antibody (H2Kk). Unfilled histogram contains unstained cells and the filled histogram stained cells. The Annals of Thoracic Surgery 2001 72, 740-745DOI: (10.1016/S0003-4975(01)02811-9)

Fig 2 Percentage survival of cardiac grafts (Kaplan-Meier method). The Annals of Thoracic Surgery 2001 72, 740-745DOI: (10.1016/S0003-4975(01)02811-9)

Fig 3 Proliferative response of lymphocytes from chimeric rats to irradiated stimulators. The Annals of Thoracic Surgery 2001 72, 740-745DOI: (10.1016/S0003-4975(01)02811-9)

Fig 4 Measurement of IgG and IgM antibody titers in the naı̈ve, chimeric, and sensitized animals. The Annals of Thoracic Surgery 2001 72, 740-745DOI: (10.1016/S0003-4975(01)02811-9)

Fig 5 Antibody-mediated cytotoxicity. The Annals of Thoracic Surgery 2001 72, 740-745DOI: (10.1016/S0003-4975(01)02811-9)