Nat. Rev. Neurol. doi:10.1038/nrneurol.2017.151 Figure 2 Definition of MRI measures and examples of brain function and structure in migraine Figure 2 The images in the imaging approaches column were reprinted by permission of the publisher Taylor and Francis Ltd. Borsook, D., Hargreaves, R. & Becerra, L. Can functional magnetic resonance imaging improve success rates in CNS drug discovery? Expert Opin. Drug Discov. 6, 597–617 (2011). The BOLD fMRI data example was adapted with permission from Burstein, R. et al. Thalamic sensitization transforms localized pain into widespread allodynia. Ann. Neurol. 68, 81–91 (2010), John Wiley and Sons. The RSN fMRI data example was adapted with permission from Li, Z. et al. The altered right frontoparietal network functional connectivity in migraine and the modulation effect of treatment. Cephalalgia 37, 161–176 (2017), SAGE Publishing. The Cortical thickening and VBM data example was adapted with permission from Maleki, N. et al. Concurrent functional and structural cortical alterations in migraine. Cephalalgia 32, 607–620 (2012), SAGE Publishing. The DTI data example was adapted with permission from Messina, R. et al. White matter microstructure abnormalities in pediatric migraine patients. Cephalalgia 35, 1278–1286 (2015), SAGE Publishing. The MRS data example was adapted with permission from Becerra, L. et al. A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients. Neuroimage Clin. 11, 588–594 (2016), Elsevier.  The images in the imaging approaches column were reprinted by permission of the publisher Taylor and Francis Ltd. Borsook, D., Hargreaves, R. & Becerra, L. Can functional magnetic resonance imaging improve success rates in CNS drug discovery? Expert Opin. Drug Discov. 6, 597–617 (2011). The BOLD fMRI data example was adapted with permission from Burstein, R. et al. Thalamic sensitization transforms localized pain into widespread allodynia. Ann. Neurol. 68, 81–91 (2010), John Wiley and Sons. The RSN fMRI data example was adapted with permission from Li, Z. et al. The altered right frontoparietal network functional connectivity in migraine and the modulation effect of treatment. Cephalalgia 37, 161–176 (2017), SAGE Publishing. The Cortical thickening and VBM data example was adapted with permission from Maleki, N. et al. Concurrent functional and structural cortical alterations in migraine. Cephalalgia 32, 607–620 (2012), SAGE Publishing. The DTI data example was adapted with permission from Messina, R. et al. White matter microstructure abnormalities in pediatric migraine patients. Cephalalgia 35, 1278–1286 (2015), SAGE Publishing. The MRS data example was adapted with permission from Becerra, L. et al. A ‘complex’ of brain metabolites distinguish altered chemistry in the cingulate cortex of episodic migraine patients. Neuroimage Clin. 11, 588–594 (2016), Elsevier.  Nyholt, D. R. et al. (2017) Migrainomics — identifying brain and genetic markers of migraine Nat. Rev. Neurol. doi:10.1038/nrneurol.2017.151