Mutations & Genetic Disorders

Stumpy, a 4-legged duckling

Mutations Essential Question: How do “mistakes” in genes change the phenotype of an organism?

Mutations mutation: a change in the genetic material

Mutations Point mutation: change in a single point in the DNA

Point Mutation

Point Mutation

Mutations Point mutation: change in a single point in the DNA substitution: one nucleotide is switched insertion/deletion: one nucleotide is added/subtracted (also called frameshift mutation)

Frameshift Mutation

Examples THE FAT CAT ATE THE RAT. Read the sentence below: What types of mutations are shown below? Which mutation makes more sense? #1: THE FIT CAT ATE THE RAT. #2: TEF ATC ATA TET HER AT. substitution deletion