Tijana Knezevic et al. BTS 2016;1:

Slides:

Advertisements

Similar presentations

Date of download: 6/9/2016 Copyright © The American College of Cardiology. All rights reserved. From: Cardiomyocyte-Specific Deletion of Gsk3α Mitigates.

Advertisements

Date of download: 6/23/2016 Copyright © The American College of Cardiology. All rights reserved. From: 17-Beta-Estradiol increases cardiac remodeling and.

Date of download: 6/25/2016 Copyright © The American College of Cardiology. All rights reserved. From: Effect of ATP-Sensitive Potassium Channel Agonists.

Figure 2 Lack of changes in current properties between myocytes

Molecular Therapy - Nucleic Acids

Daniel J. Lenihan et al. BTS 2016;1:

Neuregulins Regulate Cardiac Parasympathetic Activity

by Yanping Liu, Ken Terata, Nancy J. Rusch, and David D. Gutterman

Céline Jumeau et al. BTS 2016;j.jacbts

The magnitude of the observed DNA synthesis cannot be explained away by confounding factors.A–C.Immunocytochemistry of enzymatically dissociated myocytes.

Dendritic spine density at P30 is elevated on isolated PirB−/− neurons in layer 2/3 after sparse excision of PirB at E15.5. Dendritic spine density at.

Hui-Fang Song et al. BTS 2017;j.jacbts

Shafkat Anwar et al. BTS 2018;3:

Sven Y. Surikow et al. BTS 2018;3:

Isaac Perea-Gil et al. BTS 2016;1:

Hui-Fang Song et al. BTS 2017;2:

Hui-Fang Song et al. BTS 2017;2:

Volume 119, Issue 1, Pages (July 2000)

Hui-Fang Song et al. BTS 2017;2:

Lauren Brash et al. BTS 2018;j.jacbts

Shafkat Anwar et al. BTS 2018;3:

Heloise Mongue-Din et al. BTS 2017;2:

Holly E.M. Mewhort et al. BTS 2017;2:

Helena M. Viola et al. BTS 2018;3:

Helena M. Viola et al. BTS 2018;3:

Nikole J. Byrne et al. BTS 2017;j.jacbts

Volume 137, Issue 4, Pages (October 2009)

Isaac Perea-Gil et al. BTS 2016;1:

Dandan Wang et al. BTS 2018;3: Cardiomyocyte-Specific Knock-In miR-24 Ameliorates Ischemia/Reperfusion Injury (A) Quantitative polymerase chain.

Cardiac conduction system Cardiac conduction system. All cells of the cardiac conduction system are autorhythmic, and can depolarize and generate.

Cardiac Fibrosis at 18 Weeks Post TAC (A) Representative images (original magnification ×20) of Picrosirius red-stained cardiac tissue sections from HF +

Hironori Hara et al. BTS 2018;3:

Ioannis Smyrnias et al. JACC 2019;73:

Prachi Umbarkar et al. BTS 2019;j.jacbts

Mohamed A. Saleh et al. BTS 2016;1:

Isabelle Plaisance et al. BTS 2016;j.jacbts

Krzysztof Narkiewicz et al. BTS 2016;1:

Hironori Hara et al. BTS 2018;3:

Nat. Rev. Cardiol. doi: /nrcardio

Sven Y. Surikow et al. BTS 2018;3:

Sven Y. Surikow et al. BTS 2018;3:

Lukas J. Motloch et al. BTS 2017;2:

Masanobu Ishii et al. BTS 2017;2:

Mohamed A. Saleh et al. BTS 2016;1:

Renal Fibrosis and Plasma Creatinine Levels at 18 Weeks Post TAC (A) Plasma creatinine levels. (B) Representative images (original magnification ×20) of.

LV Structure, Function, and Circulating BNP Levels at 18 Weeks Post TAC (A) (B) LVEDD and LVESD (mm) throughout the experimental protocol. (C) Percent.

Helena M. Viola et al. BTS 2018;3:

Lauren Brash et al. BTS 2018;3:

Volume 12, Issue 1, Pages (July 2015)

Sparse excision of PirB at E15

Thomas E. Sharp III et al. BTS 2017;2:

Aortic Vasorelaxation at 18 Weeks Post TAC Freshly isolated thoracic aortic rings were allowed to equilibrate, and pre-contracted with 1 μM phenylephrine.

Nikole J. Byrne et al. BTS 2017;j.jacbts

Tomoregulin-1 improves cardiac morphology and function after pressure overload. Tomoregulin-1 improves cardiac morphology and function after pressure overload.

Tomoregulin-1 improves cardiac pathological changes after pressure overload. Tomoregulin-1 improves cardiac pathological changes after pressure overload.

Experimental Compounds and Experimental Protocol (A) Chemical structures of JK-1 and control. Hydrolysis of JK-1 yields H2S and the chemical backbone of.

Volume 24, Issue 2, Pages (February 2016)

Measurements of myocardial contractile function at rest and during dobutamine stress test (mean±SEM) in each study arm at baseline and follow-up.The change.

Leonard M. Rademakers et al. JACEP 2016;2:

Fig. 6. Prolonged miR overexpression in the adult heart reduces fibrotic scar size but compromises cardiac function after MI. Prolonged miR

Céline Jumeau et al. BTS 2016;1:

Treadmill Exercise Capacity at 18 Weeks Post TAC Exercise capacity was evaluated in all study groups at 18 weeks following TAC surgery. (A) Duration (min)

Christopher T. Nguyen et al. BTS 2018;3:97-109

Kai-Chun Yang et al. BTS 2018;3:

Heloise Mongue-Din et al. BTS 2017;2:

Michael A. Makara et al. BTS 2018;3:

Subodh Verma et al. BTS 2018;3:

Renal Norepinephrine Content, Circulating Renin, Ang II, and Aldosterone Levels at 18 Weeks Post TAC (A) Renal tissue norepinephrine content (ng/ml). (B)

Heloise Mongue-Din et al. BTS 2017;2:

Volume 112, Issue 9, Pages (May 2017)

Presentation transcript:

Tijana Knezevic et al. BTS 2016;1:647-656 BAG3 Overexpression Improves Myocyte Contractility Post-MI Myocytes were isolated from the left ventricles and septum of the 3 groups of mice (n = 3 mice each) used in Figure 1, with care being taken to excise the infarct scar in MI-GFP and -BAG3 hearts. In Sham-GFP hearts, the area corresponding to the infarct scar in MI hearts was excised before myocyte isolation. Representative contraction traces obtained in freshly isolated myocytes (2 Hz, 37°C, 1.8 mmol/l [Ca2+]o) (please see the Methods section) are shown at baseline (A) and after 1 μmol/l of isoproterenol (Iso) (B). Contraction amplitudes (C), maximal shortening (D), and re-lengthening velocities (E) are shown for Sham-GFP, MI-GFP, and MI-BAG3 myocytes, both at baseline and in the presence of isoproterenol. There are 17 Sham-GFP, 18 MI-GFP, and 25 MI-BAG3 myocytes at baseline and 21 Sham-GFP, 18 MI-GFP, and 17 MI-BAG3 myocytes after isoproterenol. Differences between groups are analyzed with 2-way analysis of variance are given in the Results section. RCL = resting call length; other abbreviations as in Figure 1. Tijana Knezevic et al. BTS 2016;1:647-656 The Authors