Remission of chronic fungal asthma in the absence of CCR8

Slides:

Advertisements

Similar presentations

Serum amyloid P attenuates M2 macrophage activation and protects against fungal spore–induced allergic airway disease Ana Paula Moreira, PhD, Karen A.

Advertisements

Innate lymphoid cells contribute to allergic airway disease exacerbation by obesity Laetitia Everaere, PhD, Saliha Ait-Yahia, PhD, Olivier Molendi-Coste,

Maternal immune response to helminth infection during pregnancy determines offspring susceptibility to allergic airway inflammation Kathrin Straubinger,

IL-4 induces IL-13–independent allergic airway inflammation

The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.

Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model Sylvie Amu, PhD, Sean P.

The activating protein 1 transcription factor basic leucine zipper transcription factor, ATF- like (BATF), regulates lymphocyte- and mast cell–driven immune.

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Allergy prevention starts before conception: Maternofetal transfer of tolerance protects against the development of asthma Tobias Polte, PhD, Christian.

Expression of IL-4 receptor α on smooth muscle cells is not necessary for development of experimental allergic asthma Frank Kirstein, PhD, William G.C.

Frank Kirstein, PhD, Natalie E

Maternal house dust mite exposure during pregnancy enhances severity of house dust mite–induced asthma in murine offspring Phoebe K. Richgels, MS, Amnah.

Pentraxin 3 deletion aggravates allergic inflammation through a TH17-dominant phenotype and enhanced CD4 T-cell survival Jyoti Balhara, MSc, Lianyu Shan,

Compartmentalized chemokine-dependent regulatory T-cell inhibition of allergic pulmonary inflammation Roshi Afshar, PhD, James P. Strassner, BS, Edward.

IL-33 dysregulates regulatory T cells and impairs established immunologic tolerance in the lungs Chien-Chang Chen, PhD, Takao Kobayashi, PhD, Koji Iijima,

Restoration of T-box–containing protein expressed in T cells protects against allergen- induced asthma Jung Won Park, MD, Hyun Jung Min, MS, Jung Ho Sohn,

Group 2 innate lymphoid cells facilitate sensitization to local, but not systemic, TH2- inducing allergen exposures Matthew J. Gold, BSc, Frann Antignano,

Leukocyte nicotinamide adenine dinucleotide phosphate-reduced oxidase is required for isocyanate-induced lung inflammation Si-Yen Liu, PhD, Wei-Zhi Wang,

CD1d restricted natural killer T cells are not required for allergic skin inflammation Abdallah Elkhal, PhD, Muriel Pichavant, PhD, Rui He, PhD, Jordan.

Allergic airway disease is unaffected by the absence of IL-4Rα–dependent alternatively activated macrophages Natalie E. Nieuwenhuizen, PhD, Frank Kirstein,

Is 9 more than 2 also in allergic airway inflammation?

Signaling through FcRγ-associated receptors on dendritic cells drives IL-33–dependent TH2-type responses Melissa Y. Tjota, BA, Cara L. Hrusch, PhD, Kelly.

Peroxisome proliferator-activated receptor α regulates skin inflammation and humoral response in atopic dermatitis Delphine Staumont-Sallé, MD, Georges.

HLA-DRB1 alleles control allergic bronchopulmonary aspergillosis–like pulmonary responses in humanized transgenic mice Sherri Koehm, BSc, Raymond G.

Early-life chlamydial lung infection enhances allergic airways disease through age- dependent differences in immunopathology Jay C. Horvat, PhD, Malcolm.

CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling Jennifer Kearley, PhD, Douglas S. Robinson,

Frank Kirstein, PhD, Natalie E

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis Mayumi Ueta, MD, PhD, Satoshi Uematsu, MD, PhD, Shizuo Akira,

Requirements for allergen-induced airway inflammation and hyperreactivity in CD4- deficient and CD4-sufficient HLA-DQ transgenic mice Svetlana P. Chapoval,

Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin–basophil axis Mario Noti,

Dendritic cells modulated by cytokine-expressing adenoviruses alleviate eosinophilia and airway hyperresponsiveness in an animal model of asthma Yi-Ling.

Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13 Rui He, MD, PhD, Hye Young Kim,

CD4-mediated regulatory T-cell activation inhibits the development of disease in a humanized mouse model of allergic airway disease Helen Martin, MS,

Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33–basophil axis in mice Nicholas Venturelli, BS, Willem S. Lexmond, MD,

Src homology 2 domain–containing inositol 5-phosphatase 1 deficiency leads to a spontaneous allergic inflammation in the murine lung Sun-Young Oh, PhD,

Programmed cell death ligand 2 regulates TH9 differentiation and induction of chronic airway hyperreactivity Jerome Kerzerho, PhD, Hadi Maazi, PhD, Anneliese.

Biosimilars and drug development in allergic and immunologic diseases

Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice Fu-Gang Zhu, PhD, Ekambar R. Kandimalla,

Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge

CC chemokine receptors CCR1 and CCR4 are expressed on airway mast cells in allergic asthma Kawa Amin, PhD, Christer Janson, MD, PhD, Ilkka Harvima, MD,

Novel allergic asthma model demonstrates ST2-dependent dendritic cell targeting by cypress pollen Lucia Gabriele, BS, Giovanna Schiavoni, BS, Fabrizio.

Intravenous immunoglobulin attenuates airway inflammation through induction of forkhead box protein 3–positive regulatory T cells Amir H. Massoud, MSc,

Monocyte-derived dendritic cell recruitment and allergic TH2 responses after exposure to diesel particles are CCR2 dependent Sharen Provoost, MSc, Tania.

Susceptibility to allergic lung disease regulated by recall responses of dual-receptor memory T cells∗ Mark A. Aronica, MD, Shadi Swaidani, MS, Yan H.

Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models Minqi Hao, MD, PhD, Stephania.

Autophagy: Nobel Prize 2016 and allergy and asthma research

Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity Iris Bellinghausen, PhD, Sebastian.

Lei Wang, MD, PhD, Jesse P. Joad, MD, Caiyun Zhong, MD, PhD, Kent E

Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection Hermelijn H.

Stephanie A. Shore, PhD, Raya D

IL-10–treated dendritic cells decrease airway hyperresponsiveness and airway inflammation in mice Toshiyuki Koya, MD, PhD, Hiroyuki Matsuda, MD, PhD,

Physiologic assessment of allergic rhinitis in mice: Role of the high-affinity IgE receptor (FcɛRI) Satoko Miyahara, MD, PhD, Nobuaki Miyahara, MD, PhD,

Serum amyloid P attenuates M2 macrophage activation and protects against fungal spore–induced allergic airway disease Ana Paula Moreira, PhD, Karen A.

Inhibition of allergic airways inflammation and airway hyperresponsiveness in mice by dexamethasone: Role of eosinophils, IL-5, eotaxin, and IL-13 Seok-Yong.

Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma

Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation Takumi Kiwamoto,

Eric B. Brandt, PhD, Melissa K. Mingler, MS, Michelle D

Ovalbumin-specific IgE modulates ovalbumin-specific T-cell response after repetitive oral antigen administration Nemuko Omata, MD, Yusei Ohshima, MD,

IL-4–independent pathways exacerbate methacholine-induced airway hyperreactivity during mycoplasma respiratory disease Matthew D. Woolard, PhD, R. Doug.

The extra domain A of fibronectin is essential for allergen-induced airway fibrosis and hyperresponsiveness in mice Martin Kohan, MSc, Andres F. Muro,

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation Takumi Kiwamoto,

Corticosteroids enhance CD8+ T cell–mediated airway hyperresponsiveness and allergic inflammation by upregulating leukotriene B4 receptor 1 Hiroshi Ohnishi,

Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease Jaclyn Smith, MD, PhD, Emily Owen, MPhil, John Earis, MD,

Natural history of cow’s milk allergy

Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge

Asthma is induced by intranasal coadministration of allergen and natural killer T-cell ligand in a mouse model Jae-Ouk Kim, PhD, Dong-Hyeon Kim, MS,

TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice Susumu Nakae, PhD, Carolina Lunderius, PhD,

Presentation transcript:

Remission of chronic fungal asthma in the absence of CCR8 Karen F. Buckland, PhD, Erica C. O'Connor, BA, Eilish M. Coleman, BSc, Sergio A. Lira, MD, PhD, Nicholas W. Lukacs, PhD, Cory M. Hogaboam, PhD Journal of Allergy and Clinical Immunology Volume 119, Issue 4, Pages 997-1004 (April 2007) DOI: 10.1016/j.jaci.2006.12.660 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Detailed examination of the features of allergic airways disease at day 3 after conidia challenge. Representative photomicrographs of hematoxylin and eosin–stained histologic lung sections from CCR8+/+(A) and CCR8−/−(B) mice; original magnification ×200. C, Serum IgE and IgG2A. D, Quantification of BAL leukocytes. E, AHR after methacholine provocation; statistical significance is compared with baseline values. F, Cytokine protein content in the lung tissue and BAL. G, Cytokine mRNA in the lung, n = 5. ∗P ≤ .05; ∗∗P ≤ .01 compared with baseline airway hyperresponsiveness in wild type; ##P ≤ .01 compared with baseline airway hyperresponsiveness in CCR8−/−. Journal of Allergy and Clinical Immunology 2007 119, 997-1004DOI: (10.1016/j.jaci.2006.12.660) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Examination of the features of allergic airways disease at day 7 after conidia challenge. Giant cells are depicted by arrows in photomicrographs of Gomori Methenamine Silver–stained histologic lung sections from CCR8+/+(A) and CCR8−/−(B) mice; original magnification ×200, representative of n = 5. C, Serum IgE and IgG2A. D, Quantification of BAL leukocytes, n = 5. E, AHR after methacholine provocation; statistical significance is compared with baseline values, n = 3-4. F, Cytokine protein content in the lung tissue and BAL, n = 5. G, Cytokine protein content in lung tissue, n = 5. ∗P ≤ .05; ∗∗P ≤ .01 compared with baseline airway hyperresponsiveness in wild type; ##P ≤ .01 compared with baseline airway hyperresponsiveness in CCR8−/−. Journal of Allergy and Clinical Immunology 2007 119, 997-1004DOI: (10.1016/j.jaci.2006.12.660) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Reduced physiological and remodeling parameters of allergic airways disease at day 14 postconidial challenge. Representative photomicrographs of periodic acid-Schiff–stained histologic lung sections from CCR8+/+(A) and CCR8−/−(B) mice; original magnification ×200. C, Serum IgE and IgG2A. D, Measurement of AHR after methacholine provocation; statistical significance is compared with baseline values. E, MUC5A mRNA detected in the lung, n = 5. ∗P ≤ .05; ∗∗P ≤ .01 compared with baseline airway hyperresponsiveness in wild type; #P ≤ .05 compared with baseline airway hyperresponsiveness in CCR8−/−. Journal of Allergy and Clinical Immunology 2007 119, 997-1004DOI: (10.1016/j.jaci.2006.12.660) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Cytokine production by antigen-restimulated splenocytes. Cytokine production by whole spleen cell populations from A fumigatus–sensitized CCR8−/−(open bars) and CCR8+/+(closed bars) mice before (ie, day 0) and at days 2 or 7 after conidia cultured for 24 hours with Con A (10 μg/mL) or A fumigatus antigens (1 μg/mL); data shown are means ± SEMs from 3 replicate wells of cells pooled from 5 mice. ∗P ≤ .05; ∗∗P ≤ .01. Journal of Allergy and Clinical Immunology 2007 119, 997-1004DOI: (10.1016/j.jaci.2006.12.660) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions