Z-score -1 1 miR167 ARF 2 Phased siRNAs Target siR362 miRNA trigger

Slides:

Advertisements

Similar presentations

NcRNA Structural 1.rRNA 2.tRNA 3.snRNA 4.snoRNA 5.cleavage: Rnases P & MRP, U3, snR30, etc Regulatory 1.Small siRNA miRNA 2.Long Activator Enhancer silencing.

Advertisements

Basics of RNA structure. RNA functions Storage/transfer of genetic information Genomes many viruses have RNA genomes single-stranded (ssRNA) e.g., retroviruses.

Transcription Definitely not Transformation, Transduction or Translocation!

1 Tyr1 Ser2 Thr4 Ser5 Ser7 Pro CTD Box 1

Figure 2 Dicer and RISC (RNA-induced silencing complex).

MicroRNA-mediated DNA methylation in plants

Protein Synthesis Part 3

Figure 1. Functional classification of positive-acting transcription factors. Major functional groups are shown in black; specific examples are illustrated.

Z-score -1 1 miR390 TAS3c Phased siRNAs Target siR506 siR406

Long Noncoding RNA in Prostate, Bladder, and Kidney Cancer

GENE REGULATION Key control mechanism for dictating cell phenotype

Protein Synthesis Part 3

Information Integration and Communication in Plant Growth Regulation

Spatial Auxin Signaling Controls Leaf Flattening in Arabidopsis

Protein Synthesis Part 3

Volume 5, Issue 4, Pages (July 2012)

Altered microRNA expression in stenoses of native arteriovenous fistulas in hemodialysis patients Lei Lv, MD, Weibin Huang, MD, Jiwei Zhang, MD, Yaxue.

Prokaryotic Development: A New Player on the Cell Cycle Circuit

Cryo-EM structure of I27[L = 35] RNCs

Raymond J. Kelleher, Arvind Govindarajan, Susumu Tonegawa Neuron

DNA transposition: Assembly of a jumping gene machine

Regulating Cancer Stem Cells the miR Way

A microRNA profile comparison between thoracic aortic dissection and normal thoracic aorta indicates the potential role of microRNAs in contributing to.

Rafael Kramann, Marcus J. Moeller Kidney International

Small RNAs Turn Over a New Leaf as Morphogens

Shogo Ito, Young Hun Song, Takato Imaizumi Molecular Plant

Figure 9. Categories of pha-siRNA-yielding genes

Figure 6. Categories of pha-siRNA-yielding genes

Charon Celine , Moreno Ana Beatriz , Bardou Florian , Crespi Martin

Phosphoinositide Function in Cytokinesis

miRC134 NBS 10 siR2331 NBS 60 ATPB miRC130a5

Supplemental Figure S4. Expression changes of phased and non-phased siRNAs among the three tissues examined The expression changes of phased and non-phased.

Edwards Allen, Zhixin Xie, Adam M. Gustafson, James C. Carrington Cell

Volume 133, Issue 1, Pages (April 2008)

DNA Methylation Mediated by a MicroRNA Pathway

Targeting AMPK in prostate cancerMT 63–78 (green burst) binds to the β1 subunit of AMPK, activating its enzymatic function. Targeting AMPK in prostate.

Marcel Klingenberg, Akiko Matsuda, Sven Diederichs, Tushar Patel

Figure 4. Differentially expressed miRNAs and isomiRNAs between different pairs of tissues The differentially expressed miRNAs and their isomiRNAs are.

Long Noncoding RNA in Hematopoiesis and Immunity

Novel functional roles of uncharacterized genes as functional regulators of cellular cholesterol levels. Novel functional roles of uncharacterized genes.

Regulation by Small RNAs in Bacteria: Expanding Frontiers

Regulation of protein phosphatase-1

The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

Figure 9. Categories of pha-siRNA-yielding genes

Prediction of Plant MicroRNA Targets

To Bloom or Not to Bloom: Role of MicroRNAs in Plant Flowering

Volume 8, Issue 7, Pages (July 2015)

Alternative Splicing in the Mammalian Nervous System: Recent Insights into Mechanisms and Functional Roles Bushra Raj, Benjamin J. Blencowe Neuron

Protein Grabs a Ligand by Extending Anchor Residues: Molecular Simulation for Ca2+ Binding to Calmodulin Loop Chigusa Kobayashi, Shoji Takada Biophysical.

Figure 7. Expression changes of phased and non-phased siRNAs among the three tissues examined The expression changes of phased and non-phased siRNAs between.

Molecular Mechanisms of Long Noncoding RNAs

MYC on the Path to Cancer

Phosphatase Specificity and Pathway Insulation in Signaling Networks

Alexander Kiani, Anjana Rao, Jose Aramburu Immunity

Volume 16, Issue 9, Pages (May 2006)

Crystal structures of Nova-1 and Nova-2 K-homology RNA-binding domains

HEAT repeats as part of large protein complexes.

Figure 2 Signalling downstream of the IL-6 receptor

Schematic of proteins identified by RNA affinity purification-coupled LC-MS/MS and the hnRNPH-associated protein network recruited by the G-containing.

miRC134 NBS 10 siR2331 NBS 60 ATPB miRC130a5

Volume 12, Issue 3, Pages (March 2019)

Volume 7, Issue 2, Pages R19-R23 (February 1999)

Genome-wide Functional Analysis Reveals Factors Needed at the Transition Steps of Induced Reprogramming Chao-Shun Yang, Kung-Yen Chang, Tariq M. Rana

DNA transposition: Assembly of a jumping gene machine

A Splicing-Independent Function of SF2/ASF in MicroRNA Processing

Cell Signaling by Receptor Tyrosine Kinases

Photosynthesis: Regulation by redox signalling

Distinct subtypes of CAFs are detected in human PDAC

Ending the Message Is Not So Simple

The Tangled Web of Signaling in Innate Immunity

Presentation transcript:

Z-score -1 1 miR167 ARF 2 Phased siRNAs Target siR362 miRNA trigger -1 1 Z-score Phased siRNAs Target siR362 ARF2 SNRP SFS miRNA trigger miR167 siR1878 KC PI-PLC SmLP HAL Non-phased siRNAs ARF 2 Cis-cleavage KFP PSI GRF ARF ARO CHLII GT BG siR1697 siR2456 siR2296 ARF 2 PK PTA siR479 NEB RIP Figure 9. miR167-directed pha-siRNA regulatory pathway The miR167 directed pha-siRNA regulatory pathway is shown as indicated. The blue arrows and lines show the regulatory pathway of pha-siRNA s produced from ARF2, while the dark orange arrows and lines show the regulatory pathway of cis-cleavage by nonpha-siRNA, siR1697. The broken green and dark blue arrows show two potential auto-regulated pathway of Auxin by phased and non-phased siRNAs. The colors in the boxes from left to right represent the Z-score of expression values of sRNAs in the leaf, flower and boll, respectively. ARF (2): Auxin response factor (2); SNRP: small nucleolar RNA-associated protein; SFS: Splicing factor subunit; KC: kafirin cluster; PI-PLC : PI-PLC X domain-containing protein; SmLP: snRNA-associated Sm-like protein; HAL: PAP-specific phosphatase HAL2-like family protein; BG: Beta-galactosidase; GT: Glycosyltransferase; KFP: Kinase family protein; PSI: Photosystem I chain III family protein; GRF: GRF1-INTERACTING FACTOR 2 family protein; ARO: ARO1-like protein; CHLII: hlorophyll A/B binding protein; NEB: Neurobeachin; RIP: 60S ribosomal protein L5.