F.H. Engbers, N Sutcliffe, G Kenny, S Schraag

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Pharmacokinetic models for propofol: defining and illuminating the devil in the detail F.H. Engbers, N Sutcliffe, G Kenny, S Schraag British Journal of Anaesthesia Volume 104, Issue 2, Pages 261-264 (February 2010) DOI: 10.1093/bja/aep385 Copyright © 2010 The Author(s) Terms and Conditions

Fig 1 Relationship between k10 and LBM, weight and height. Solid lines: calculated from the Schnider formula with no constraint on LBM. Dashed lines: only LBM limited to maximum, as suggested in the article. Dotted lines: LBM and weight and height limited to the point where LBM maximizes, which is the situation in the TCI systems. British Journal of Anaesthesia 2010 104, 261-264DOI: (10.1093/bja/aep385) Copyright © 2010 The Author(s) Terms and Conditions

Fig 2 Influence of total body weight and height on the k10 calculated by the Schnider model [(a) males; (b) females] as implemented in the latest versions of commercially available ‘open TCI’ systems. The heavy black and grey lines indicate the range of TBW values within which the systems will operate for patients who are 160 and 190 cm tall, respectively. The light black and grey lines indicate the k10 values which would result from application of the original Schnider equation for k10 outside of the aforementioned ranges. Finally, the dotted lines indicate the k10 values that result if the systems fix the LBM at the maximum value, and use TBW generating that maximum LBM value, for patients 160 and 190 cm tall, respectively (designated as ‘corrected LBM, TBW’). British Journal of Anaesthesia 2010 104, 261-264DOI: (10.1093/bja/aep385) Copyright © 2010 The Author(s) Terms and Conditions