Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled.

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Effects of metformin and leuprolide acetate on insulin resistance and testosterone levels in nondiabetic postmenopausal women: a randomized, placebo-controlled trial  Shrita M. Patel, M.D., M.S.C.E., Nayyar Iqbal, M.D., M.S.C.E., Shailja Kaul, M.B.B.S., Sarah J. Ratcliffe, Ph.D., Michael R. Rickels, M.D., M.S., Muredach P. Reilly, M.B., M.S.C.E., Theresa Scattergood, R.N., M.S.N., Arpita Basu, M.B.B.S., Carissa Fuller, C.R.N.P., Anne R. Cappola, M.D., Sc.M.  Fertility and Sterility  Volume 94, Issue 6, Pages 2161-2166 (November 2010) DOI: 10.1016/j.fertnstert.2010.01.064 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Longitudinal data for (A) free T, (B) calculated free T, (C) total T, (D) sex hormone-binding globulin (SHBG), (E) homeostasis model assessment of insulin resistance (HOMA-IR), and (F) insulin by group. Mean values with SE bars are presented. P values are for longitudinal comparisons to placebo of log-transformed values. Fertility and Sterility 2010 94, 2161-2166DOI: (10.1016/j.fertnstert.2010.01.064) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Longitudinal data for (A) LH, (B) FSH, (C) E2, and (D) DHEAS by group. Mean values with SE bars are presented. P values are for longitudinal comparisons to placebo. DHEAS values were log-transformed for analysis. Fertility and Sterility 2010 94, 2161-2166DOI: (10.1016/j.fertnstert.2010.01.064) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

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