DFP-induced astrogliosis is reduced by urethane.

Slides:



Advertisements
Similar presentations
FMRP suppresses dendritic Arc protein levels.
Advertisements

Activation of Src Family Kinases in Spinal Microglia Contributes to Formalin-Induced Persistent Pain State Through p38 Pathway  Yong-Hui Tan, Kai Li,
Fig. 2. Expression of Ninj1 in cortices of ischemic hemispheres of rat brains at 1 day post-MCAO. Coronal brain sections were prepared at 1 day post-MCAO.
Prevention of seizures and reorganization of hippocampal functions by transplantation of bone marrow cells in the acute phase of experimental epilepsy 
Dendritic spine density at P30 is elevated on isolated PirB−/− neurons in layer 2/3 after sparse excision of PirB at E15.5. Dendritic spine density at.
Density of dendritic spines on L2/3 pyramidal neurons is greater in visual cortex of germline PirB−/− mice than in PirB+/+ mice at P30. Density of dendritic.
Analysis of brain and spinal cord of treated Gaa−/− mice and controls
Histologic evaluation of albumin extravasation during early epileptogenesis. Histologic evaluation of albumin extravasation during early epileptogenesis.
Urethane reduces the frequency of spontaneous recurrent seizures six to eight weeks following 1 h of DFP-induced SE. A, Cortical EEG activity was recorded.
Activation of PBN and CeA by illuminating the hindpaw after PNI
Type 1 NSPCs express nestin, ApoE, and GFAP, while mature granule cells make connections with astrocytes expressing ApoE and GFAP. A–D, Representative.
IONC increased non-PrV2-origin lemniscal fiber terminals in V2 VPM related to newly recruited lemniscal fibers onto VPM neurons. IONC increased non-PrV2-origin.
Fig. 3. Morphological changes associated with glial activation were reduced in 16-month-old APP/PS1;C3 KO mice. Morphological changes associated with glial.
GlyR activation modulates its diffusion properties around active synapses. GlyR activation modulates its diffusion properties around active synapses. A,
HDAC4N increases with Braak stage in CA2 hippocampal pyramidal cells.
The effects of KY19382 on chondrocyte proliferation and differentiation. The effects of KY19382 on chondrocyte proliferation and differentiation. (A) ATDC5.
Adenosine-induced osteogenic differentiation of hiPSCs involves A2bR
TOR, but not OSP, blocks STx2B transport and alters endosomal dynamics
OTX2 transfers into supporting cells of neurogenic niches.
CRISPRa induction of Bdnf transcript variants I and IV in primary rat hippocampal neurons. CRISPRa induction of Bdnf transcript variants I and IV in primary.
The complexity as well as the total dendritic length of ApoE-deficient adult-born granule cells are significantly reduced. The complexity as well as the.
The complexity and the total dendritic length of ApoE4 adult-born granule cells are significantly reduced. The complexity and the total dendritic length.
CIS causes a reduction in GFAP-positive astrocytes in BA but not in dCA3. CIS causes a reduction in GFAP-positive astrocytes in BA but not in dCA3. A,
Fig. 2. Deficiency of neuronal HS leads to reduced neuroinflammation.
Activation of glial cells.
Effect of FGF8 on R-C marker expression.
Fig. 4. Reduction of apoptosis and autophagic stress by treatment with silibinin in the KA-treated hippocampus. (A, B) Double-immunofluorescence staining.
Diclofenac treatment reduces L-selectin on peripheral blood and infiltrated leukocytes but does not alter accumulation in the injured spinal cord. Diclofenac.
Phosphorylated CREB levels were assessed in the hippocampus at 20 min after cue and contextual fear conditioning. Phosphorylated CREB levels were assessed.
Fig. 3. Neuroprotective effects of silibinin against KA-induced excitotoxicity. (A) Silibinin was intraperitoneally injected for 8 days, starting 1 day.
Fig. 5. Anti-inflammatory effects of silibinin on KA treatment in the hippocampus. (A) Representative coronal sections of the hippocampal CA1 region following.
LOTUS reduced axonal dieback in CST fibers following SCI
Double immunostaining of P2X7R and cell-specific markers in morphine-tolerated rats. Double immunostaining of P2X7R and cell-specific markers in morphine-tolerated.
Deletion of HtrA1 does not alter vascular or immune cell morphology or distribution in the young-adult mouse neocortex. Deletion of HtrA1 does not alter.
Microglia activation in distinct sites of the spinal cord from mice with bronchial asthma or atopic dermatitis on the back skin at the thoracic spinal.
ASyn overexpression exacerbates the effect of MPP+ on Ca2+ in SN but not VTA neurons. aSyn overexpression exacerbates the effect of MPP+ on Ca2+ in SN.
c-Fos in RFMes GABAergic neurons across groups.
Engagement of PDGF-αR and PDGF-βR is critical for PDGF-BB-mediated increased proliferation of NPCs. RT-PCR (A) and WB (B) of PDGF-αR and PDGF-βR in NPCs;
Chronic SSRI treatment rescued lOFC hyperactivity in QNP-treated mice.
Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. A,
NF-κB is central to the relationship between UA and cognitive dysfunction. NF-κB is central to the relationship between UA and cognitive dysfunction. The.
PTZ-induced c-Fos and Arc proteins in hippocampal dentate gyrus
PTZ-induced neuronal activity visualized by IEGs
IHC detection of p-mTOR Ser 2448 in subcortical white matter during postnatal rat CNS development. IHC detection of p-mTOR Ser 2448 in subcortical white.
Effect of PPARγ agonist on Aβ phagocytosis in primary microglia.
Tissue distribution of MMP-9 and MMP-2 in adult rat brain.
Peripheral surgery regulates expression of astrocytic markers.
Stress-induced monocyte accumulation in the brain and the neurovascular induction of ICAM-1 were prevented by ADX. Male C57BL/6 mice were subjected to.
Mast cell and microglial proliferation in the developing POA
Double-immunofluorescence labeling of Arg-1 in WT (A) and IL-10−/− (C) mice at 3 (i) and 7 (ii) days postinjury (dpi). Double-immunofluorescence labeling.
GABAARs in RFMes GABAergic neurons across groups.
MET-1 increases DRG neuron K+ currents.
Fig. 3. Morphological changes associated with glial activation were reduced in 16-month-old APP/PS1;C3 KO mice. Morphological changes associated with glial.
FMRP S499 rephosphorylation kinetics after CX-4945 treatment and washout mirrors a known CK2 target. FMRP S499 rephosphorylation kinetics after CX-4945.
CPARs in the NAc protect against depression-like behaviors induced by chronic pain. CPARs in the NAc protect against depression-like behaviors induced.
Gld2 and Ngd regulate glycine-induced GluN2A synthesis and surface expression in dendrites. Gld2 and Ngd regulate glycine-induced GluN2A synthesis and.
Astrocyte number and morphologic status assessed by GFAP immunohistochemistry in E3FAD and E4FAD mice across dietary treatments. Astrocyte number and morphologic.
Absence of PC-induced ischemic tolerance in P2X7−/− mice.
Rate of current rundown through VDCC and NMDA receptor channels is reduced in gelsolin-deficient hippocampal neurons. Rate of current rundown through VDCC.
FKBP1b counters the age-related decrease in hippocampal MAP2 protein expression. FKBP1b counters the age-related decrease in hippocampal MAP2 protein expression.
SLC30A10 protects DAergic neurons from neurodegeneration induced by Mn exposure. SLC30A10 protects DAergic neurons from neurodegeneration induced by Mn.
At P23, dendritic spine density on L2/3 pyramidal cells in PirB−/− visual cortex is similar to that of PirB+/+. At P23, dendritic spine density on L2/3.
Optogenetically stimulated Aβ fibers induce pain-like behaviors after PNI. A, B, Withdrawal score by light (A) and paw withdrawal threshold by von Frey.
Candesartan diminishes SynO-mediated morphofunctional responses in microglia. Candesartan diminishes SynO-mediated morphofunctional responses in microglia.
UA acts as an inflammatory stimulus and activates NF-κB in hippocampus
CA1 neuronal loss and recovery following forebrain ischemia.
Fig. 3. LPS induces degeneration of DA neurons and microglial activation in the SN in vivo. LPS (5 µg/3 µl) was unilaterally injected into the SN in the.
Passive immunization with CT α-syn antibodies improved TH pathology and neuroinflammation in the striatum of α-syn tg mice. Passive immunization with CT.
A, B, 5-HT1A immunoreactivity in hippocampal dendrites (CA3) of saline-treated (A) and fluoxetine-treated (B) rats. A, B, 5-HT1A immunoreactivity in hippocampal.
BDNF protein is expressed in neurons and astrocytes of hippocampus after pilocarpine-induced SE. A, Representative confocal images of hippocampal subfields.
Presentation transcript:

DFP-induced astrogliosis is reduced by urethane. DFP-induced astrogliosis is reduced by urethane. Representative images (taken with a 10× objective lens) showing positive GFAP immunostaining (A) as an astrocyte marker and Iba1 immunofluorescence staining (B) as a microglial marker in the hippocampal CA3 region (DAB with a Nissl counterstain). Four days after DFP-induced SE, astrogliosis, and microgliosis were obvious in the sections obtained from rats as defined by the increased number of positively labeled cells in rats that experienced uninterrupted SE and rats administered diazepam 1 h after SE onset but not as much in sections taken from rats injected with urethane 1 h following SE onset or non-seizure controls. Scale bar, 100 μm. C, Induction of GFAP, CD11B and Iba1 mRNA in the forebrain 4 d following DFP SE in rats that experienced uninterrupted SE (n = 7), rats administered diazepam 1 h after SE onset-treated (n = 9 rats) and urethane-treated (1 h SE) rats (n = 13 rats; ***p < 0.001, one-way ANOVA with post hoc Bonferroni). Asheebo Rojas et al. eNeuro 2018;5:ENEURO.0070-18.2018 ©2018 by Society for Neuroscience