Valproic acid (VPA) synergises with VAC (mafosfamide, doxorubicin and vindesine) to induce apoptosis in small cell lung carcinoma (SCLC) cell lines. Valproic.

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Valproic acid (VPA) synergises with VAC (mafosfamide, doxorubicin and vindesine) to induce apoptosis in small cell lung carcinoma (SCLC) cell lines. Valproic acid (VPA) synergises with VAC (mafosfamide, doxorubicin and vindesine) to induce apoptosis in small cell lung carcinoma (SCLC) cell lines. Three SCLC cell lines (H146, H526 and H69) were cultivated during 24 h with or without VPA (1 mM) in combination with mafosfamide (10 µM), vindesine (20 nM) and doxorubicin (0.3 µM). Apoptosis rates were determined by flow cytometry after ethanol fixation and propidium iodide staining. Cells in sub-G1 phase represent apoptotic cells with fragmented DNA. The percentages of cells undergoing apoptosis are presented as mean±sd of three independent experiments. For clarity, Student's t-tests between conditions and their associated control are indicated above individual conditions. *: p<0.05; **: p<0.01; ***: p<0.001. Roland Hubaux et al. ERJ Open Res 2015;1:00028-2015 ©2015 by European Respiratory Society