NF-κB/Rel/IκB: Implications in gastrointestinal diseases

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Presentation transcript:

NF-κB/Rel/IκB: Implications in gastrointestinal diseases Roland M. Schmid, Guido Adler Gastroenterology Volume 118, Issue 6, Pages 1208-1228 (June 2000) DOI: 10.1016/S0016-5085(00)70374-X Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 Structure of NF-κB, Rel, and IκB proteins. Gastroenterology 2000 118, 1208-1228DOI: (10.1016/S0016-5085(00)70374-X) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 Different signals converge at a multisubunit kinase complex that contains the IκB kinases α (IKKα) and β (IKKβ). Gastroenterology 2000 118, 1208-1228DOI: (10.1016/S0016-5085(00)70374-X) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 The induction of NF-κB/Rel–mediated transcription can be blocked at several levels. Gastroenterology 2000 118, 1208-1228DOI: (10.1016/S0016-5085(00)70374-X) Copyright © 2000 American Gastroenterological Association Terms and Conditions