Acute kidney failure with renal carcinomatous lymphangitis secondary to advanced colon cancer  Thomas Robert, Anissa Moktefi, Helge Wiig, Isabelle Brochériou, Laure Michaud, Joseph Gligorov, Serge Finianos, Alexandre Hertig  Kidney International  Volume 84, Issue 2, (August 2013) DOI: 10.1038/ki.2012.480 Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 1 Carcinomatous lymphangitis of the kidney. Hematoxylin and eosin staining of the renal biopsy sample (magnification × 200) showing dilated vessels containing tumor cells arranged in glandular formation. Right corner: tumor cells characterized by mucin vacuoles in the cytoplasm (periodic acid–Schiff staining, magnification × 1000). Kidney International 2013 84, DOI: (10.1038/ki.2012.480) Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 2 Immunohistochemical findings. (a) The lymphatic nature of the vessels is attested by positive staining with an anti-D2-40 antibody (counterstaining with periodic acid–Schiff stain, magnification × 1000). (b) Positive staining for the intestine-specific homeobox protein CDX2 was observed in the nuclei, which confirmed the colonic origin of the tumor cells (magnification × 1000); no expression of CK7 was detectable (not shown). Kidney International 2013 84, DOI: (10.1038/ki.2012.480) Copyright © 2013 International Society of Nephrology Terms and Conditions