Volume 56, Pages S70-S75 (July 1999) Atherogenic lipoproteins and tyrosine kinase mitogenic signaling in mesangial cells  Vaijinath S. Kamanna, Ph.D, Babu V. Bassa, Nosratola D. Vaziri, Daeyoung D. Roh  Kidney International  Volume 56, Pages S70-S75 (July 1999) DOI: 10.1046/j.1523-1755.1999.07118.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Signal transduction paradigm for cell proliferation. Cellular mitogenic stimulus can induce the autophosphorylation and activation of intrinsic tyrosine kinase activity of specific membrane receptors, which, in turn, can sequentially activate Ras, Raf, and MAP kinase. The activated cytoplasmic MAP kinase translocates into the nucleus and activates various transcription factors and proto-oncogenes associated with cell proliferation. PKC and G-protein–mediated events can also activate MAP kinase signaling. Atherogenic lipoproteins, by activating specific membrane receptors, may induce the activation of Ras-MAP kinase signaling. Kidney International 1999 56, S70-S75DOI: (10.1046/j.1523-1755.1999.07118.x) Copyright © 1999 International Society of Nephrology Terms and Conditions