John E. Levine, Sophie Paczesny, Stefanie Sarantopoulos

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Presentation transcript:

Clinical Applications for Biomarkers of Acute and Chronic Graft-versus-Host Disease John E. Levine, Sophie Paczesny, Stefanie Sarantopoulos Biology of Blood and Marrow Transplantation Volume 18, Issue 1, Pages S116-S124 (January 2012) DOI: 10.1016/j.bbmt.2011.10.019 Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Biomarker research steps. Biology of Blood and Marrow Transplantation 2012 18, S116-S124DOI: (10.1016/j.bbmt.2011.10.019) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Biologically relevant BAFF and B cell markers in plasma, blood, and bone marrow. (A) Naive and transitional B cells are increased in patients without cGVHD, and these may serve as predictive markers of good post-HSCT health. (B) Low transitional and naive B cell numbers and high BAFF/B cell ratios may serve as markers of cGVHD. Biology of Blood and Marrow Transplantation 2012 18, S116-S124DOI: (10.1016/j.bbmt.2011.10.019) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Possible randomized, double-blinded, placebo-controlled, trial design to test GVHD preemption. Biology of Blood and Marrow Transplantation 2012 18, S116-S124DOI: (10.1016/j.bbmt.2011.10.019) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions