Study algorithm for SIMPLE study Study algorithm for SIMPLE study. CRF, clinical report form; CXR, chest X-ray; EQ-5D-5L, EuroQoL 5 Dimensions 5 Levels; MPE, malignant pleural effusion; TUS, thoracic ultrasound; VAS, Visual Assessment Scale. Study algorithm for SIMPLE study. CRF, clinical report form; CXR, chest X-ray; EQ-5D-5L, EuroQoL 5 Dimensions 5 Levels; MPE, malignant pleural effusion; TUS, thoracic ultrasound; VAS, Visual Assessment Scale. Ioannis Psallidas et al. BMJ Open Resp Res 2017;4:e000225 ©2017 by British Thoracic Society