Aaron Deykin, MD, Stephen C. Lazarus, MD, John V

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Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids Aaron Deykin, MD, Stephen C. Lazarus, MD, John V. Fahy, MD, ChB, Michael E. Wechsler, MD, MMSc, Homer A. Boushey, MD, Vernon M. Chinchilli, PhD, Timothy J. Craig, DO, Emily Dimango, MD, Monica Kraft, MD, Frank Leone, MD, Robert F. Lemanske, MD, Richard J. Martin, MD, Gene R. Pesola, MD, MPH, Stephen P. Peters, MD, PhD, Christine A. Sorkness, PharmD, Stanley J. Szefler, MD, Elliot Israel, MD Journal of Allergy and Clinical Immunology Volume 115, Issue 4, Pages 720-727 (April 2005) DOI: 10.1016/j.jaci.2004.12.1129 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Schematic diagram of the SOCS study and the time points for Feno measurement, methacholine PC20 measurement, and sputum induction included in the analysis. Journal of Allergy and Clinical Immunology 2005 115, 720-727DOI: (10.1016/j.jaci.2004.12.1129) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Box plots of sputum eosinophil counts (A), sputum ECP levels (B), Feno values (C), and methacholine PC20 values (D) in each of the treatment groups at randomization and after 2 weeks of double-blind therapy. By convention, the horizontal bar represents the median value, the length of the box represents the interquartile range, and the whiskers are drawn to the nearest value not beyond 1.5 interquartile range from the quartiles. Differences between time points were assessed by using the Sign test for Feno values and sputum eosinophil counts and the Student t test for methacholine PC20 values. Journal of Allergy and Clinical Immunology 2005 115, 720-727DOI: (10.1016/j.jaci.2004.12.1129) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Modeled asthma outcomes on the basis of the data from the SOCS trial of 1000 subjects with mild-to-moderate asthma treated with standard continuous ICSs (A) and those of 1000 similar asthmatic subjects selectively withdrawn from ICSs on the basis of sputum eosinophil changes during a short trial discontinuation period (B). See text for details. Journal of Allergy and Clinical Immunology 2005 115, 720-727DOI: (10.1016/j.jaci.2004.12.1129) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions