Douglas E. Gladstone, Andrea A. Zachary, Ephraim J

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Presentation transcript:

Partially Mismatched Transplantation and Human Leukocyte Antigen Donor-Specific Antibodies Douglas E. Gladstone, Andrea A. Zachary, Ephraim J. Fuchs, Leo Luznik, Yvette L. Kasamon, Karen E. King, Robert A. Brodsky, Richard J. Jones, Mary S. Leffell Biology of Blood and Marrow Transplantation Volume 19, Issue 4, Pages 647-652 (April 2013) DOI: 10.1016/j.bbmt.2013.01.016 Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 The antibody course during desensitization and posthematopoietic stem cell transplantation is illustrated for patient 5. The donor-specific antibody (DSA) is shown by the line with closed circles. Third-party antibody course is illustrated by the line with squares and the positive control values for each assay are indicated by the triangles. The relative antibody strength is indicated by the mean fluorescence intensity values (MFI) determined with single-antigen immunoassays. Before desensitization, the DSA resulted in a positive flow cytometric crossmatch (FCXM+). Biology of Blood and Marrow Transplantation 2013 19, 647-652DOI: (10.1016/j.bbmt.2013.01.016) Copyright © 2013 American Society for Blood and Marrow Transplantation Terms and Conditions