Contrast medium-induced nephropathy: The pathophysiology

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Contrast medium-induced nephropathy: The pathophysiology P.B. Persson, M. Tepel Kidney International Volume 69, Pages S8-S10 (April 2006) DOI: 10.1038/sj.ki.5000367 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 Mitochondrial function in a proximal tubular cell line is impaired after 24-h treatment of contrast media (CM). Function was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction. (a) The comparison of the effects of various CM on 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction reveal significant differences from one another (P<0.01) in the pioneer study by Hardieck et al.14 The least influence was found by the low-osmolality agents, followed by the iso-osmolality CM (Iodixanol). The ionic substances showed the greatest effect. (b) Heinrich et al.21 discovered no significant differences between the dimers and the low-osmolality monomers. However, ioxithalamate caused a significantly greater reduction in 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. Kidney International 2006 69, S8-S10DOI: (10.1038/sj.ki.5000367) Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 2 An iso-osmolality and highly viscous dimer, Iotrolan, increases urine viscosity to a considerably greater degree than ionic and monomeric contrast media. With permission from Ueda et al.22 Kidney International 2006 69, S8-S10DOI: (10.1038/sj.ki.5000367) Copyright © 2006 International Society of Nephrology Terms and Conditions