Fig. 1 Anti-LtxA antibody concentrations in various patient groups.

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Fig. 1 Anti-LtxA antibody concentrations in various patient groups.

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Fig. 1 Anti-LtxA antibody concentrations in various patient groups. Anti-LtxA antibody concentrations in various patient groups. (A) Serum antibodies to leukotoxin A (LtxA) were measured in periodontitis patients with and without Aa infection (n = 16 per group) confirmed by culturing. (B) Distribution of anti-LtxA antibodies in sera of 594 patients suffering from early arthritis and 156 controls. Concentrations of anti-LtxA antibodies in the serum of each individual are shown. (C) Serum antibodies to LtxA were measured in rheumatoid arthritis (RA) patients stratified for the presence of anti–cyclic citrullinated peptide 2 (CCP2) antibodies, classified as anti-citrullinated protein antibody (ACPA)–positive (n = 214) and ACPA-negative (n = 155) RA patients (left). Presence of anti-LtxA antibodies is shown in sera of RA patients carrying HLA-DRB1 shared epitope (SE) alleles, classified as SE-positive (n = 243) and SE-negative (n = 117) RA patients (right). OA, inflammatory osteoarthritis; SpA, spondyloarthritis with peripheral arthritis, PsA, psoriatic arthritis; Sarc, sarcoidosis. Red lines indicate the median for each group, and error bars indicate interquartile ranges. The dashed line indicates the cutoff for positivity. The number of patients per group and percentage of patients positive according to the cutoff are shown underneath. Mann-Whitney test was used for statistical comparison of antibody concentrations between (i) RA patients and other subgroups, (ii) ACPA-positive and ACPA-negative patients, and (iii) SE-positive and SE-negative patients. Significant differences are indicated by corresponding P values. AU, arbitrary units. Mikhail Volkov et al., Sci Transl Med 2018;10:eaan8349 Published by AAAS