Volume 9, Issue 1, Pages (October 2002)

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Volume 9, Issue 1, Pages 27-32 (October 2002) Prevention of apoptosis by deferoxamine during 4 hours of cold cardioplegia and reperfusion: in vitro study of isolated working rat heart model Petr Dobšák, J Siegelova, J.E Wolf, L Rochette, J.C Eicher, J Vasku, S Kuchtickova, M Horky Pathophysiology Volume 9, Issue 1, Pages 27-32 (October 2002) DOI: 10.1016/S0928-4680(02)00054-8

Fig. 1 Effect of DFX on cardiac output (ml/min per g of wet heart) during preischemic period and reperfusion. Results are expressed as the mean±S.D. (□ controls, ■ DFX 50 μM, **P<0.01; ***P<0.001). Pathophysiology 2002 9, 27-32DOI: (10.1016/S0928-4680(02)00054-8)

Fig. 2 Detection of apoptotic cardiomyocytes using TdT-mediated biotin–dUTP nick-end labeling (TUNEL) technique in the group “DFX 50 μM” (a) and the group “controls” (b). Arrows indicate examples of apoptotic cardiomyocytes (magnification 100×, counterstaining with hematoxyline). Pathophysiology 2002 9, 27-32DOI: (10.1016/S0928-4680(02)00054-8)

Fig. 3 Percentage of nuclei staining positive for TUNEL in heart tissue samples after 4 h of global cold ischemia and 45 min of reperfusion in the group “DFX 50 μM” and the group “controls”. (DFX=deferoxamine, *P<0.05 vs. group “controls”). Pathophysiology 2002 9, 27-32DOI: (10.1016/S0928-4680(02)00054-8)

Pathophysiology 2002 9, 27-32DOI: (10.1016/S0928-4680(02)00054-8)

Pathophysiology 2002 9, 27-32DOI: (10.1016/S0928-4680(02)00054-8)