Antinociceptive effects of tetrodotoxin (TTX) in rodents

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Antinociceptive effects of tetrodotoxin (TTX) in rodents J. Marcil, J.-S. Walczak, J. Guindon, A.H. Ngoc, S. Lu, P. Beaulieu British Journal of Anaesthesia Volume 96, Issue 6, Pages 761-768 (June 2006) DOI: 10.1093/bja/ael096 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 1 Formalin test in male rats (n=10 per group). Animals received a s.c. injection of 0.9% NaCl (control), TTX (in µg kg−1) or morphine (5 mg kg−1) 30 min before 2.5% formalin injection into the dorsum of the hind paw. Pain scores are quantified using the CPS–WST (a). Acute (0–15 min) (b) and inflammatory (20–50 min) (c) phases of the formalin test. *P<0.05 compared with control. British Journal of Anaesthesia 2006 96, 761-768DOI: (10.1093/bja/ael096) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 2 The writhing test in male mice consisted of the injection of 0.6% acetic acid i.p. 30 min after a s.c. injection of 0.9% NaCl (control), TTX (in µg kg−1) or morphine (5 mg kg−1). The number of writhes (abdominal contractions) was measured between 5 and 15 min after the injection (n=10 per group). *P<0.05 compared with control. British Journal of Anaesthesia 2006 96, 761-768DOI: (10.1093/bja/ael096) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 3 Mechanical allodynia testing in rats using von Frey filaments on the ipsilateral (operated paw, main figure) and contralateral (upper figure) paws the day before surgery (J0), 12 days after surgery (J12) and on the 13th day (treatment) when animals received a s.c. injection of 0.9% NaCl, TTX at 0.3, 1, 3 or 6 µg kg−1, or morphine (5 mg kg−1). Data are expressed as mean (sem) (n=6). *P<0.05 for treatment with 0.9% NaCl vs different treatments. British Journal of Anaesthesia 2006 96, 761-768DOI: (10.1093/bja/ael096) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 4 Thermal hyperalgesia evaluation in rats using the plantar test on the ipsilateral (operated paw, main figure) and contralateral (upper figure) paws the day before surgery (J0), 12 days after surgery (J12) and on the 13th day (treatment) when animals received a s.c. injection of 0.9% NaCl, TTX at 0.3, 1, 3 or 6 µg kg−1, or morphine (5 mg kg−1). Data are expressed as mean (sem) (n=6). *P<0.05 for treatment with 0.9% NaCl vs different treatments. British Journal of Anaesthesia 2006 96, 761-768DOI: (10.1093/bja/ael096) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions