Prothrombin complex concentrate mitigates diffuse bleeding after cardiopulmonary bypass in a porcine model F Kaspereit, S Hoffmann, I Pragst, G Dickneite

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Prothrombin complex concentrate mitigates diffuse bleeding after cardiopulmonary bypass in a porcine model F Kaspereit, S Hoffmann, I Pragst, G Dickneite British Journal of Anaesthesia Volume 105, Issue 5, Pages 576-582 (November 2010) DOI: 10.1093/bja/aeq216 Copyright © 2010 The Author(s) Terms and Conditions

Fig 1 Study design. CPB, cardiopulmonary bypass; PCC, prothrombin complex concentrate; SBT, skin bleeding time. British Journal of Anaesthesia 2010 105, 576-582DOI: (10.1093/bja/aeq216) Copyright © 2010 The Author(s) Terms and Conditions

Fig 2 Individual animal levels of (a) FII, (b) FVII, (c) FIX, and (d) FX at baseline and after CPB and subsequent administration of PCC. Concentration values expressed as percentages of the baseline means, shown as dashed lines. CPB, cardiopulmonary bypass; FII, factor II; FVII, factor VII; FIX, factor IX; FX, factor X; PCC, prothrombin complex concentrate. British Journal of Anaesthesia 2010 105, 576-582DOI: (10.1093/bja/aeq216) Copyright © 2010 The Author(s) Terms and Conditions

Fig 3 Individual animal suture hole blood losses after CPB and administration of saline or PCC in comparison with those of a control group which did not undergo CPB. Horizontal lines indicate median values. CI, 95% confidence interval; CPB, cardiopulmonary bypass; PCC, prothrombin complex concentrate. British Journal of Anaesthesia 2010 105, 576-582DOI: (10.1093/bja/aeq216) Copyright © 2010 The Author(s) Terms and Conditions

Fig 4 Peak thrombin generation in individual animals at baseline and after CPB and subsequent administration of saline or PCC. Medians depicted as horizontal lines. In the table inset, grouped comparison indicated between saline and PCC; all other comparisons paired. CI, 95% confidence interval; CPB, cardiopulmonary bypass; PCC, prothrombin complex concentrate. British Journal of Anaesthesia 2010 105, 576-582DOI: (10.1093/bja/aeq216) Copyright © 2010 The Author(s) Terms and Conditions