XBP1s and RIDD of mRNA signals in GBM XBP1s and RIDD of mRNA signals in GBM Schematic representation of the signaling characteristics of IRE1 variants based on data generated in Fig 2, toward XBP1 mRNA splicing, RIDD of mRNA, and RIDD of miR‐17.Intersection of the upregulated genes in WT, P336L, and A414T‐expressing cells as the hallmark of XBP1s expression. A list of 40 genes was established and confronted to the tumor transcriptomes of the GBMmark cohort (Appendix Table S2). XBP1s high and XBP1s low groups of tumors were established.Expression analysis of IBA1, CD31, and RHOA mRNA in the XBP1s high (red; n = 44) and low (green; n = 75) groups of tumors. Horizontal lines indicate median; box lines indicate first & third quartiles; whiskers indicate min & max. Student's t‐test was used with Welch's correction when SD different.Characterization of XBP1s high and low tumors using immunohistochemistry (no XBP1s expression (1), and increasing amounts of XBP1s expression (2–4) are shown).Correlation of XBP1s and IBA1 staining.Intersection of the list of RNA cleaved by IRE1 in vitro (Appendix Table S3) and that of mRNA whose expression is upregulated in IRE1‐DN cells under basal conditions.A list of 37 genes was established and confronted to the tumor transcriptomes of the GBMmark cohort. RIDDhigh and RIDDlow groups of tumors were established.Expression analysis of IBA1, CD31, and RHOA mRNA was evaluated in the RIDDhigh (red; n = 64) and RIDDlow (green; n = 55) groups of tumors (I). Horizontal lines indicate median; box lines indicate first & third quartiles; whiskers indicate min & max. Student's t‐test was used with Welch's correction when SD different. Stéphanie Lhomond et al. EMBO Mol Med. 2018;emmm.201707929 © as stated in the article, figure or figure legend