Matrix metalloproteinases and matrix receptors in progression and reversal of kidney disease: therapeutic perspectives Pierre Ronco, Christos Chatziantoniou

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Matrix metalloproteinases and matrix receptors in progression and reversal of kidney disease: therapeutic perspectives Pierre Ronco, Christos Chatziantoniou Kidney International Volume 74, Issue 7, Pages 873-878 (October 2008) DOI: 10.1038/ki.2008.349 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Proposed involvement of DDR1 in chronic renal disease: AngII induces collagen synthesis simultaneously and increases DDR1 expression; collagen binds DDR1 and induces phosphorylation of its intracellular part. This activation of DDR1 stimulates the p38 pathway, which in turn leads to cytokine activation. Cytokine release further stimulates collagen synthesis and DDR1 expression. Thus, DDR1 participates in a positive cross talk between inflammation and ECM synthesis, which ultimately leads to chronic renal failure. Kidney International 2008 74, 873-878DOI: (10.1038/ki.2008.349) Copyright © 2008 International Society of Nephrology Terms and Conditions