Variation of glucose tolerance in adult patients with cystic fibrosis: What is the potential contribution of insulin sensitivity?  Valérie Boudreau, Adèle Coriati, Imane Hammana, Sophie Ziai, Katherine Desjardins, Yves Berthiaume, Rémi Rabasa-Lhoret  Journal of Cystic Fibrosis  Volume 15, Issue 6, Pages 839-845 (November 2016) DOI: 10.1016/j.jcf.2016.04.004 Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Transition of glucose tolerance status after two 2-hour OGTT (1.75g/kg of glucose) in adult patients with CF (N=152) over 21.2±5.5months. Full line, improved glucose tolerance; dotted line, stable glucose tolerance; bold line, deteriorated glucose tolerance. Abbreviations: NGT, Normal glucose tolerance; IGT, Impaired glucose tolerance; CFRD, Cystic fibrosis-related diabetes. Journal of Cystic Fibrosis 2016 15, 839-845DOI: (10.1016/j.jcf.2016.04.004) Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Disposition index for A) stable, B) deteriorated and C) improved glucose tolerance groups. Total insulin secretion index was adjusted for insulin sensitivity index for each transition group of glucose tolerance (n=84 patients from the stable group, n=22 from the improved group and n=46 from the deteriorated group). AUC0-120 during OGTT reflects the total insulin secretion index, and the insulin sensitivity index represents the Stumvoll index. White diamond, Baseline; Black square, Follow-up. Arrows indicate transition from baseline to follow-up. Data are represented as ±SEM. Journal of Cystic Fibrosis 2016 15, 839-845DOI: (10.1016/j.jcf.2016.04.004) Copyright © 2016 European Cystic Fibrosis Society. Terms and Conditions