Biosynthesis and Usage of Lysine

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Biosynthesis and Usage of Lysine Group 4: 資工系博士班 904325 彭千華資工系博士班 918309 彭士齊資工系博士班 918317 徐婕婷資工系博士班 938342 張家銘

Introduction of Lysine Lysine (C6H14N2O2 ) ~ an essential basic amino acid ~ net positive charge ~ commonly found on the surfaces of proteins and enzymes, and sometimes appears in the active site.

Finding a pathway of Lysine http://www.genome.jp/kegg/

Finding a pathway of Lysine

Finding a pathway of Lysine

Finding a pathway of Lysine

Graph of Glycolysis http://www.genome.jp/kegg/

Graph of TCA cycle http://www.genome.jp/kegg/

Graph of Aspartate Metabolism http://www.genome.jp/kegg/

Graph of Lysine Biosynthesis http://www.genome.jp/kegg/

Biosynthesis of Threonine and Methionine http://www.genome.jp/kegg/

al

R39 R30 R31 R32 R33 R34 R35 R36 R37 R38

R41 R40 R39

R42 R43 R44

max R38 subject to R1=100 R1-R2=0 R2-R3=0 R3-R4=0 R4-R5=0 R5-R6=0 R6-R7=0 R7-R8=0 R8-R9-R16=0 R9-R10=0 R10-R11=0 R11-R12=0 R12-R13-R17=0 R13-R14=0 R14-R15=0 R16+R28-R29=0 R17-R18=0 R18-R19=0 R19-R20=0 R20-R21=0 R21-R22=0 R22-R23=0 R23-R24=0 R24-R25=0 R25-R26=0 R26-R27=0 R27-R28=0 R29-R30=0 R30-R31=0 R31-R39-R32=0 R32-R33=0 R33-R34=0 R34-R35=0 R35-R36=0 R36-R37=0 R37-R38=0 R40-R41=0 R39-R40-R42=0 R42-R43=0 R43-R44=0 -100<=Ri<=100

Simplex Method

Results Input data: E.coli reactions (KEGG) Result1 Result2 : Wild-type (bound: -100~100, glucose=100) Methionine=0, Threonine=0, Lysine=47.5 Result2 : Mutant (Methionine=0, Threonine=0, glucose=100) Methionine=0, Threonine=0, Lysine=0

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