The effects of intra-articular glucocorticoids and exercise on pain and synovitis assessed on static and dynamic magnetic resonance imaging in knee osteoarthritis:

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Presentation transcript:

The effects of intra-articular glucocorticoids and exercise on pain and synovitis assessed on static and dynamic magnetic resonance imaging in knee osteoarthritis: exploratory outcomes from a randomized controlled trial R.G.C. Riis, M. Henriksen, L. Klokker, C. Bartholdy, K. Ellegaard, E. Bandak, B.B. Hansen, H. Bliddal, M. Boesen Osteoarthritis and Cartilage Volume 25, Issue 4, Pages 481-491 (April 2017) DOI: 10.1016/j.joca.2016.10.009 Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Synovitis on DCE-MRI. A–C: creation of the “Gd-enhancement-sequence” (C) by subtracting the first repetition of the DCE-MRI sequence (A) from the last repetition (B). ROIs are drawn around the enhancing synovium on the Gd-enhancement-sequence and automatically transposed to the motion corrected DCE-MRI sequence. The dark areas represent effusion and were included in the ROIs as this does not influence any of the DCE-MRI parameters/variable (effusion is non-enhancing and thus registered as none-enhancing voxels in Dynamika and no DCE-MRI parameters are calculated for such voxels). The inclusion of effusion in DCE-MRI analyses of synovitis has been used before12. D–E: parametric maps. Brighter colors indicate higher values. (D): IRE-map; (E): Ktrans-map. Osteoarthritis and Cartilage 2017 25, 481-491DOI: (10.1016/j.joca.2016.10.009) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Trial profile. *mITT (n = 91); Ø: circumference. Osteoarthritis and Cartilage 2017 25, 481-491DOI: (10.1016/j.joca.2016.10.009) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions