Re‐expression of the AXIN1 coding sequence re‐sensitizes VACO6R cells to PORCN inhibition Re‐expression of the AXIN1 coding sequence re‐sensitizes VACO6R.

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Re‐expression of the AXIN1 coding sequence re‐sensitizes VACO6R cells to PORCN inhibition Re‐expression of the AXIN1 coding sequence re‐sensitizes VACO6R cells to PORCN inhibition qRT–PCR evaluation of PTPRK‐RSPO3 fusion transcript expression in VACO6, VACO6R, and HCT116 cells, as indicated. Data are expressed as means ± SD of three technical replicates from one representative experiment.Western blot showing AXIN1 protein expression in VACO6R, VACO6, and VACO6RAXIN1FL cells, as indicated.Flow cytometry analysis of the GFP signal in VACO6, VACO6R, and VACO6RAXIN1FL cells, all transduced with the 7xTcf‐eGFP WNT reporter.ATP‐based assay measuring viability, after 6 days of LGK974 treatment, of parental VACO6, VACO6R, and VACO6RAXIN1FL cells, as indicated. Data are expressed as average ± SD of six technical replicates. Source data are available online for this figure. Gabriele Picco et al. EMBO Mol Med. 2017;emmm.201606773 © as stated in the article, figure or figure legend