Involvement of actin cytoskeletal reorganisation in EMT

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Presentation transcript:

Involvement of actin cytoskeletal reorganisation in EMT Figure 1 from Morris and Machesky British Journal of Cancer Advance Online Publication 22 January 2015 doi:10.1038/bjc.2014.658 Several approaches exist to target Eph receptors. Kinase inactivating strategies include kinase inhibitors or blocking peptides or antibodies. Kinase activating strategies include ligand stimulation, activating antibodies or ligand peptide mimetics Strategies to deliver toxic payloads following receptor activation and internalisation include coupling of cytotoxic agents or radionuclides to Eph monoclonal antibodies. © 2015 Cancer Research UK.