Volume 115, Issue 6, Pages 1395-1404 (December 1998) Sialyl-Tn antigen as a marker of colon cancer risk in ulcerative colitis: Relation to dysplasia and DNA aneuploidy Per Karlén, Eric Young, Olle Broström, Robert Löfberg, Bernhard Tribukait, Åke Öst, Carol Bodian, Steven Itzkowitz Gastroenterology Volume 115, Issue 6, Pages 1395-1404 (December 1998) DOI: 10.1016/S0016-5085(98)70018-6 Copyright © 1998 American Gastroenterological Association Terms and Conditions
Fig. 1 (A–F) Comparison of STn, aneuploidy, and dysplasia in 6 case-control pairs in study A. Numbers at the top represent colonic segments from the cecum (1) to rectum (10) as described in Patients and Methods. Each segment was analyzed for STn expression, aneuploidy, and dysplasia. Unmarked segments indicate nondysplastic, diploid, STn-negative mucosa. Shaded boxes indicate STn-positive specimens (defined as >5% crypts expressing STn antigen). Aneuploidy is indicated by “An.” Dysplasia, when present, is indicated below each entry. Slashes indicate tissue not available for STn analysis. LGD, low-grade dysplasia; HGD, high-grade dysplasia. Gastroenterology 1998 115, 1395-1404DOI: (10.1016/S0016-5085(98)70018-6) Copyright © 1998 American Gastroenterological Association Terms and Conditions
Fig. 1 (A–F) Comparison of STn, aneuploidy, and dysplasia in 6 case-control pairs in study A. Numbers at the top represent colonic segments from the cecum (1) to rectum (10) as described in Patients and Methods. Each segment was analyzed for STn expression, aneuploidy, and dysplasia. Unmarked segments indicate nondysplastic, diploid, STn-negative mucosa. Shaded boxes indicate STn-positive specimens (defined as >5% crypts expressing STn antigen). Aneuploidy is indicated by “An.” Dysplasia, when present, is indicated below each entry. Slashes indicate tissue not available for STn analysis. LGD, low-grade dysplasia; HGD, high-grade dysplasia. Gastroenterology 1998 115, 1395-1404DOI: (10.1016/S0016-5085(98)70018-6) Copyright © 1998 American Gastroenterological Association Terms and Conditions
Fig. 1 (A–F) Comparison of STn, aneuploidy, and dysplasia in 6 case-control pairs in study A. Numbers at the top represent colonic segments from the cecum (1) to rectum (10) as described in Patients and Methods. Each segment was analyzed for STn expression, aneuploidy, and dysplasia. Unmarked segments indicate nondysplastic, diploid, STn-negative mucosa. Shaded boxes indicate STn-positive specimens (defined as >5% crypts expressing STn antigen). Aneuploidy is indicated by “An.” Dysplasia, when present, is indicated below each entry. Slashes indicate tissue not available for STn analysis. LGD, low-grade dysplasia; HGD, high-grade dysplasia. Gastroenterology 1998 115, 1395-1404DOI: (10.1016/S0016-5085(98)70018-6) Copyright © 1998 American Gastroenterological Association Terms and Conditions
Fig. 1 (A–F) Comparison of STn, aneuploidy, and dysplasia in 6 case-control pairs in study A. Numbers at the top represent colonic segments from the cecum (1) to rectum (10) as described in Patients and Methods. Each segment was analyzed for STn expression, aneuploidy, and dysplasia. Unmarked segments indicate nondysplastic, diploid, STn-negative mucosa. Shaded boxes indicate STn-positive specimens (defined as >5% crypts expressing STn antigen). Aneuploidy is indicated by “An.” Dysplasia, when present, is indicated below each entry. Slashes indicate tissue not available for STn analysis. LGD, low-grade dysplasia; HGD, high-grade dysplasia. Gastroenterology 1998 115, 1395-1404DOI: (10.1016/S0016-5085(98)70018-6) Copyright © 1998 American Gastroenterological Association Terms and Conditions
Fig. 1 (A–F) Comparison of STn, aneuploidy, and dysplasia in 6 case-control pairs in study A. Numbers at the top represent colonic segments from the cecum (1) to rectum (10) as described in Patients and Methods. Each segment was analyzed for STn expression, aneuploidy, and dysplasia. Unmarked segments indicate nondysplastic, diploid, STn-negative mucosa. Shaded boxes indicate STn-positive specimens (defined as >5% crypts expressing STn antigen). Aneuploidy is indicated by “An.” Dysplasia, when present, is indicated below each entry. Slashes indicate tissue not available for STn analysis. LGD, low-grade dysplasia; HGD, high-grade dysplasia. Gastroenterology 1998 115, 1395-1404DOI: (10.1016/S0016-5085(98)70018-6) Copyright © 1998 American Gastroenterological Association Terms and Conditions
Fig. 1 (A–F) Comparison of STn, aneuploidy, and dysplasia in 6 case-control pairs in study A. Numbers at the top represent colonic segments from the cecum (1) to rectum (10) as described in Patients and Methods. Each segment was analyzed for STn expression, aneuploidy, and dysplasia. Unmarked segments indicate nondysplastic, diploid, STn-negative mucosa. Shaded boxes indicate STn-positive specimens (defined as >5% crypts expressing STn antigen). Aneuploidy is indicated by “An.” Dysplasia, when present, is indicated below each entry. Slashes indicate tissue not available for STn analysis. LGD, low-grade dysplasia; HGD, high-grade dysplasia. Gastroenterology 1998 115, 1395-1404DOI: (10.1016/S0016-5085(98)70018-6) Copyright © 1998 American Gastroenterological Association Terms and Conditions
Fig. 2 Expression of STn antigen in patients in study B, group III, who had aneuploidy at some time in the past but no dysplasia. See legend to Figure 1 for definition of symbols. Gastroenterology 1998 115, 1395-1404DOI: (10.1016/S0016-5085(98)70018-6) Copyright © 1998 American Gastroenterological Association Terms and Conditions
Fig. 2 Expression of STn antigen in patients in study B, group III, who had aneuploidy at some time in the past but no dysplasia. See legend to Figure 1 for definition of symbols. Gastroenterology 1998 115, 1395-1404DOI: (10.1016/S0016-5085(98)70018-6) Copyright © 1998 American Gastroenterological Association Terms and Conditions