Clinical evaluation of leukocyte-depleted blood cardioplegia for pediatric open heart operation Yoshitaka Hayashi, MD, Yoshiki Sawa, MD, Motonobu Nishimura,

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Clinical evaluation of leukocyte-depleted blood cardioplegia for pediatric open heart operation Yoshitaka Hayashi, MD, Yoshiki Sawa, MD, Motonobu Nishimura, MD, Hajime Ichikawa, MD, Koji Kagisaki, MD, Shigeaki Ohtake, MD, Hikaru Matsuda, MD The Annals of Thoracic Surgery Volume 69, Issue 6, Pages 1914-1919 (June 2000) DOI: 10.1016/S0003-4975(00)01298-4

Fig 1 Schematic of leukocyte-depleted blood cardioplegia procedure. The Annals of Thoracic Surgery 2000 69, 1914-1919DOI: (10.1016/S0003-4975(00)01298-4)

Fig 2 Change in the depletion ratios of leukocytes. The depletion ratio with the leukocyte removal filter remained at a relatively high level even after several administrations of cardioplegia (CP solution). The Annals of Thoracic Surgery 2000 69, 1914-1919DOI: (10.1016/S0003-4975(00)01298-4)

Fig 3 Comparison of myocardial protective effects between the blood cardioplegia solution (BCP) and the leukocyte-depleted blood cardioplegia solution (LDBCP) groups. (CS-Ao MDA = difference in plasma concentration of malondialdehyde between coronary sinus effluent blood and arterial blood; HH-FABP = human heart fatty acid-binding protein in the plasma obtained 50 minutes after reperfusion; max CK-MB = the peak concentration of plasma creatine kinase-MB during the first 24 hours postoperatively; catecholamine = the maximum dose of catecholamine, dopamine plus dobutamine, required at the time of weaning from cardiopulmonary bypass and during the postoperative course.) The Annals of Thoracic Surgery 2000 69, 1914-1919DOI: (10.1016/S0003-4975(00)01298-4)

Fig 4 Representative electron micrographs of the fibers of the leukocyte removal filter. A large number of blood cells, which were regarded as white blood cells, were captured on the fibers of the leukocyte removal filter. (A, ×500; B, ×1,500; C, ×5,000.) The Annals of Thoracic Surgery 2000 69, 1914-1919DOI: (10.1016/S0003-4975(00)01298-4)