Volume 138, Issue 4, Pages 1357-1364.e2 (April 2010) SAFETY Study: Alanine Aminotransferase Cutoff Values Are Set Too High for Reliable Detection of Pediatric Chronic Liver Disease  Jeffrey B. Schwimmer, Winston Dunn, Gregory J. Norman, Perrie E. Pardee, Michael S. Middleton, Nanda Kerkar, Claude B. Sirlin  Gastroenterology  Volume 138, Issue 4, Pages 1357-1364.e2 (April 2010) DOI: 10.1053/j.gastro.2009.12.052 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 Inclusion and exclusion for National Health and Nutrition Examination Survey (NHANES) reference population. Gastroenterology 2010 138, 1357-1364.e2DOI: (10.1053/j.gastro.2009.12.052) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 Receiver operating characteristic (ROC) curves for alanine aminotransferase (ALT) in boys. Shown are the sensitivity and [1-specificity] of ALT in detecting hepatitis B viral infection (A), hepatitis C viral infection (B), and nonalcoholic fatty liver disease (C). Plotted along the ROC curves are the ALT thresholds currently utilized by children's hospitals (marked with “x”) and the biologically derived ALT threshold (marked with “o”). The numbers on the ROC curves represent the median and interquartile range of ALT thresholds currently used by children's hospitals, as well as the biologically derived ALT threshold. Gastroenterology 2010 138, 1357-1364.e2DOI: (10.1053/j.gastro.2009.12.052) Copyright © 2010 AGA Institute Terms and Conditions

Figure 3 Receiver operating characteristic (ROC) curves for alanine aminotransferase (ALT) in girls. Shown are the sensitivity and [1-specificity] of ALT in detecting hepatitis B viral infection (A), hepatitis C viral infection (B), and nonalcoholic fatty liver disease (C). Plotted along the ROC curves are the ALT thresholds currently utilized by children's hospitals (marked with “x”) and the biologically derived ALT threshold (marked with “o”). The numbers on the ROC curves represent the median and interquartile range of ALT thresholds currently used by children's hospitals, as well as the biologically derived ALT threshold. Gastroenterology 2010 138, 1357-1364.e2DOI: (10.1053/j.gastro.2009.12.052) Copyright © 2010 AGA Institute Terms and Conditions