Administration of granulocyte colony-stimulating factor enhances endothelialization and microvessel formation in small-caliber synthetic vascular grafts

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Presentation transcript:

Administration of granulocyte colony-stimulating factor enhances endothelialization and microvessel formation in small-caliber synthetic vascular grafts Vishwanath Bhattacharya, MDa,b, Qun Shi, MDa,b, Atsushi Ishida, MD, PhDa,b, Lester R. Sauvage, MD a,b,c, William P. Hammond, MDa,b,d, Moses Hong-De Wu, MDa,b Journal of Vascular Surgery Volume 32, Issue 1, Pages 116-123 (July 2000) DOI: 10.1067/mva.2000.107308 Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Figure. Comparison of representative areas of G-CSF grafts with control grafts from untreated subjects. A, A′, Gross specimens. B, B′, Map of ELCC distribution, showing that cellular coverage on the control grafts was largely restricted to the pannus areas. The views for C, C′ through H, H′ are of areas in the centers of the grafts. C, C′, ELCC delineated by AgNO3 staining, C = ×55, C′ = ×30. Views from D, D′ : hematoxylin and eosin staining. D = ×55. D′ = ×55. E, E′, CD34 staining, showing endothelial cells and microvessels. Inset for E shows endothelial cells and microvessels with apparent origin on the flow surface. E = ×45, E′ = ×45. F, F′, Smooth muscle α-actin staining. Inset for F shows multiple layers of smooth muscle cells in the neointima. F = ×50, F′ = ×50. G, G′, Scanning electron microscopy. G = ×320; G′ = ×480. H, H′, Transmission electron microscopy. H = ×1300, H′ = ×2700. Journal of Vascular Surgery 2000 32, 116-123DOI: (10.1067/mva.2000.107308) Copyright © 2000 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions