Gross pathology and histopathology of asthma

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Presentation transcript:

Gross pathology and histopathology of asthma Qutayba Hamid, PhD, Editor Journal of Allergy and Clinical Immunology Volume 111, Issue 2, Pages 431-432 (February 2003) DOI: 10.1067/mai.2003.147 Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Biopsy from the proximal airways of a normal, nonasthmatic subject shows an intact epithelium containing a small number of goblet cells and inflammatory cells in the submucosa. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 1 Biopsy from the proximal airways of a normal, nonasthmatic subject shows an intact epithelium containing a small number of goblet cells and inflammatory cells in the submucosa. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Cross section of a small airway (<2 mm in diameter) shows an intact epithelium that is lined by cuboidal cells and a thin layer of smooth muscle around the airway. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 2 Cross section of a small airway (<2 mm in diameter) shows an intact epithelium that is lined by cuboidal cells and a thin layer of smooth muscle around the airway. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 3 Section from the proximal airway of a patient who died of status asthmaticus shows many of the classic pathologic changes described in asthma. In particular, note the eosinophilic plug, a detached epithelium, subepithelium, thickening, smooth muscle hyperplasia/hypertrophy, and the marked inflammatory infiltrate. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 3 Section from the proximal airway of a patient who died of status asthmaticus shows many of the classic pathologic changes described in asthma. In particular, note the eosinophilic plug, a detached epithelium, subepithelium, thickening, smooth muscle hyperplasia/hypertrophy, and the marked inflammatory infiltrate. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 4 Gross pathology of lung of asthmatic patient who died of status asthmaticus. There are notable hemorrhagic changes, edema, and hyperinflation from obstruction of the small airways. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 4 Gross pathology of lung of asthmatic patient who died of status asthmaticus. There are notable hemorrhagic changes, edema, and hyperinflation from obstruction of the small airways. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 5 Endoscopic biopsy from a patient with chronic moderate asthma shows partial epithelial detachment and hypertrophy of smooth muscle layer with close approximation to the epithelium. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 5 Endoscopic biopsy from a patient with chronic moderate asthma shows partial epithelial detachment and hypertrophy of smooth muscle layer with close approximation to the epithelium. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 6 Endoscopic biopsy from a patient with severe asthma shows mucus hyperplasia, extensive thickening of the subepithelial layer and marked infiltration of inflammatory cells—in particular, eosinophils. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 6 Endoscopic biopsy from a patient with severe asthma shows mucus hyperplasia, extensive thickening of the subepithelial layer and marked infiltration of inflammatory cells—in particular, eosinophils. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 7 Cross section of a small airway from a patient who died of complications from severe chronic asthma shows extensive airway remodeling of the small airways with increased smooth muscle mass and collagen deposition. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 7 Cross section of a small airway from a patient who died of complications from severe chronic asthma shows extensive airway remodeling of the small airways with increased smooth muscle mass and collagen deposition. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 8 Cross section of a small airway from a patient with chronic severe asthma shows eosinophilic infiltrate in the submucosa and in the area of the smooth muscle. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions

Fig. 8 Cross section of a small airway from a patient with chronic severe asthma shows eosinophilic infiltrate in the submucosa and in the area of the smooth muscle. Journal of Allergy and Clinical Immunology 2003 111, 431-432DOI: (10.1067/mai.2003.147) Copyright © 2003 Mosby, Inc. Terms and Conditions