Colleen G. Koch, MD, MS, MBA, Edward R

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Presentation transcript:

When the timing is right: Antibiotic timing and infection after cardiac surgery Colleen G. Koch, MD, MS, MBA, Edward R. Nowicki, MD, MS, Jeevanantham Rajeswaran, MSc, Steven M. Gordon, MD, Joseph F. Sabik, MD, Eugene H. Blackstone, MD The Journal of Thoracic and Cardiovascular Surgery Volume 144, Issue 4, Pages 931-937.e4 (October 2012) DOI: 10.1016/j.jtcvs.2012.01.087 Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Distribution of antibiotic timing stratified by antibiotic status (cefuroxime, gray line; vancomycin, black line). Vertical dashed lines represent current protocol guidelines for administration. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 931-937.e4DOI: (10.1016/j.jtcvs.2012.01.087) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Percentage of postoperative sternal wound infections by time for cefuroxime antibiotic prophylaxis. Solid line represents estimated percentages of infection enclosed within dashed 68% bootstrapped percentile confidence intervals. Symbols represent data grouped within time frame to provide a crude verification of model fit. Vertical dashed lines represent current protocol time frame for administration. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 931-937.e4DOI: (10.1016/j.jtcvs.2012.01.087) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Percentage of postoperative sternal wound infections by time for vancomycin antibiotic prophylaxis. Format is as in Figure 2. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 931-937.e4DOI: (10.1016/j.jtcvs.2012.01.087) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 CONSORT diagram of patient population. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 931-937.e4DOI: (10.1016/j.jtcvs.2012.01.087) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure E2 Distribution of patient-specific optimal timing in cefuroxime group. A, Overall; B, body mass index; C, diabetes; and D, bilateral ITA grafts. ITA, Internal thoracic artery. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 931-937.e4DOI: (10.1016/j.jtcvs.2012.01.087) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure E3 Distribution of patient-specific optimal timing in vancomycin group. A, Overall; B, body mass index; C, diabetes; D, bilateral ITA grafts. ITA, Internal thoracic artery. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 931-937.e4DOI: (10.1016/j.jtcvs.2012.01.087) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions