Nanoparticles for enhancing the effectiveness of proton therapy

Slides:



Advertisements
Similar presentations
Energy deposition and neutron background studies for a low energy proton therapy facility Roxana Rata*, Roger Barlow* * International Institute for Accelerator.
Advertisements

PRACTICAL RADIATION PHYSICS FOR EMERGENCY MEDICAL PERSONNEL Module III.
Boron Neutron Capture Therapy
D.G.Lewis Department of Medical Physics Velindre Cancer Centre Whitchurch, Cardiff RT-GRID: Grid Computing for Radiotherapy.
Radiation Exposure, Dose and Relative Biological Effectiveness in Medicine Background Image:
Tumour Therapy with Particle Beams Claus Grupen University of Siegen, Germany [physics/ ] Phy 224B Chapter 20: Applications of Nuclear Physics 24.
Interactions of charged particles with the patient I.The depth-dose distribution - How the Bragg Peak comes about - (Thomas Bortfeld) II.The lateral dose.
Radiation Dosimetry Dose Calculations D, LET & H can frequently be obtained reliably by calculations: Alpha & low – Energy Beta Emitters Distributed in.
Part 1 Introduction to Radiotherapy and External Beam Radiation Deepak Khuntia, MD Vice President, Medical Affairs Varian Medical Systems.
ACADs (08-006) Covered Keywords Roentgen, gray, exposure rates, absorbed dose, dose equivalent, quality factors, linear energy transfer, relative biological.
At the position d max of maximum energy loss of radiation, the number of secondary ionizations products peaks which in turn maximizes the dose at that.
Ionising Radiation.
Theoretical calculations and simulations of interaction of X-rays with high-Z nanomoities for use in cancer radiotherapy Sara N. Lim, Anil K. Pradhan,
Radiation all Around Us Radon gas, cosmic rays, medical x- rays, food and body chemicals.
TRAINING COURSE ON RADIATION DOSIMETRY: Radiobiology Basics – RBE, OER, LET Anthony WAKER University of Ontario Institute of Technology Thu. 22/11/2012,
Radiation therapy is based on the exposure of malign tumor cells to significant but well localized doses of radiation to destroy the tumor cells. The.
Targeted Gold Nanoparticles as Vascular Disrupting Agents during Radiation Therapy RI Berbeco 1, H Korideck 1, S Kunjachan 1, R Kumar 2, S Sridhar 2, A.
The Skandion clinic, plans for the use of particle beams for radiation therapy in Sweden presented by Erik Grusell, medical radiation physicist Dept of.
PAMELA Contact Author: CONFORM is an RCUK-funded Basic Technology Programme Charged Particle Therapy Treating cancer with protons and light ions Ken Peach,
DMI 261 Radiation Biology AndProtection. Unit 2 RADIATION Electromagnetic Spectrum –The frequency range of electromagnetic radiation and the photon wavelength.
Applications of Geant4 in Proton Radiotherapy at the University of Texas M.D. Anderson Cancer Center Jerimy C. Polf Assistant Professor Department of Radiation.
First Year Workshop 2014 Miriam Lafiandra
G. Bartesaghi, 11° ICATPP, Como, 5-9 October 2009 MONTE CARLO SIMULATIONS ON NEUTRON TRANSPORT AND ABSORBED DOSE IN TISSUE-EQUIVALENT PHANTOMS EXPOSED.
Using Radiation in Medicine. There are 3 main uses of radiation in medicine: Treatment Diagnosis Sterilization.
Page  1 A new method to measure 10 B uptake in lung adenocarcinoma in hospital BNCT D. Bolognini, E.M. Donegani, A. Mattera, M. Prest, S. Hasan E. Capelli,
Training Module 3 – Version 1.1 For Internal Use Only ® Radiation Therapy 
Interactions of radiation with Matter
1 Interaction Between Ionizing Radiation And Matter, Part 3 Neutrons Audun Sanderud Department of Physics University of Oslo.
TUDelft-IRI-ST A new Tissue-Equivalent Proportional Counter design M. Farahmand, A.J.J. Bos, J. Huizenga and C.W.E. van Eijk Radiation Technology Group,
Basic Biologic Interactions of Radiation IONIZATION.
M Asnal *, T Liamsuwan 2 and T Onjun 1 1 Sirindhorn International Institute of Technology, Thammasat University 2 Nuclear Research and Development Division,
Authorization and Inspection of Cyclotron Facilities Radiation Fields.
3/2003 Rev 1 II.2.9a – slide 1 of 25 IAEA Post Graduate Educational Course Radiation Protection and Safe Use of Radiation Sources Part IIQuantities and.
Namur Research Institute for Life Science IN VITRO RADIOBIOLOGY AND RELATED TOPICS: description of some fundamental research performed with a low energy.
Photoneutron Distributions around 18 MV X-ray Radiotherapy Accelerators using Nuclear Track Detectors Fazal-ur-Rehman, H. Al-Ghamdi, M. I. Al-Jarallah.
Nuclear medicine Essential idea Nuclear radiation, whilst dangerous owing to its ability to damage cells and cause mutations, can also be used to both.
Clinical Application of Carbon Therapy
BNCT, a binary radiotherapy at cellular level
1 NANO AMPLIFIED THERAPY INFN-Milano, INFN-Torino, INFN-Pisa, INFN- Roma3, CNR-Pisa, University of Torino - Biotechnology Department.
RBE: open issues and next challenges Francesco Tommasino Workshop: la radiobiologia in INFN Trento, Maggio 2016.
Particle Therapy at GSI
Methods & Materials (continued)
Linear Energy Transfer and Relative Biological Effectiveness
Nuclear medicine Essential idea
Understanding Radiation Therapy Lecturer Radiological Science
Radiological Protection in Ion Beam Radiotherapy
From Microdosimetry to Nanodosimetry
Review or Introduction to Atomic and Nuclear Physics
Combined effect of charged particles irradiation and anticancer drugs in cultured tumor cells.(RDH_IRPT WP2; INFN_Milano, CNAO and Istituto Tumori) The.
INTERACTION OF PARTICLES WITH MATTER
Chapter 5 Interactions of Ionizing Radiation
EURADOS Working Group 9: Radiation Dosimetry in Radiotherapy
Very High Energy Electron for Radiotherapy Studies
Dose Equivilant Rad Pro III NUCP 2331.
Radiation Units.
International Workshop on radiosensitization
Interactions of Radiation With Matter
A Comparative Study of Biological Effects of VHEE, Protons and other Radiotherapy Modalities Kristina Small University of Manchester, Christie NHS Foundation.
Development and characterization of the Detectorized Phantom for research in the field of spatial fractionated radiation therapy. D. Ramazanov, V. Pugatch,
أجهزة العلاج الإشعاعي Clinical Radiation Generator
Lecture 10: Nanodrug Design and Methods of Activation
M. D. Anderson Cancer Center Houston, TX
AAPM Annual Meeting, Anaheim, California July 13, 2015
Rad T 110 Sherer Ch. 3.
Neutron Detection with MoNA LISA
Radiation Safety sidpec 11/24/2018.
Outside the nucleus, the beta decay {image} will not occur because the neutron and electron have more total mass than the proton. This process can occur.
Figure 5 The biological effects of charged particles
Nuclear medicine Essential idea
Geant4 at IST Applications in Brachytherapy
Presentation transcript:

Nanoparticles for enhancing the effectiveness of proton therapy Pawel Olko Bronowice Cyclotron Centre, Institute of Nuclear Physics PAN, Kraków, Poland

Methods of cancer treatment Surgery Chemotherapy Radiation therapy External radiotherapy Brachytherapy Targeted radiotherapy BNCT …….

Radiotherapy is not always successful Glioblastoma Pancreatic ductal adenocarcinoma aggressive, frequent recurrence difficulties in diagnosis and treatment enhanced tumour radio-resistance and low radiation tolerance of neighbouring healthy tissu BNCT Clinical studies with C-ions Chiba, Japan Heidelberg, Germany Is it possible to improve effectivness of proton therapy by introducing nanoparticles to target volume?

Outline Rationale of proton therapy Physics and microdosimetry of nanoparticles Future work https://mappingignorance.org

Rationale of proton therapy Dose distribution Verification Low scattered radiation Radiobiology Conformal dose distribution results in saving healthy tissue

Intensity Modulated Proton Therapy, IMPT Court. Engelsmann, PSI

Rationale of proton therapy Dose distribution Verification Low scattered radiation Radiobiology Verification of range/ dose distribution using the PET/prompt gamma techniques

Rationale of proton therapy Dose distribution Verification Low scattered radiation Radiobiology Distant doses from scattered radiation 10-100 times lower in PT than in classical MV X-rays

Rationale of proton therapy Dose distribution Verification Low scattered radiation Radiobiology Protons Belli et al. 2000 Bettega et al. 1979 Relative Biological Effectivness increases for low energy protons

Proton therapy – low LET radiation? BEAM BEAM Say the same configuration as before Nuclear reactions -> secondaries Explain LET method Secondary ions Protons L. Grzanka, NEUDOS-13, 2017

Can we locally increase energy deposition?

Boron Neutron Capture Therapy 10B + nth → [11B] *→ α + 7Li + 2.31 MeV Ea = 1.47 MeV , Range ~ 9 um, LET~ 190 keV/um

Photon interactions with high Z elements – photoelectric effect Mass energy absorption coefficent for gold (Z=79)

Dose enhancement for orthovoltage X-rays on high-Z elements

Nanoparticles Particles: 1-100 nm Large surface as compared to total amount Mainly Ni, Fe, Au, Pt M. Parlińska, IFJ PAN

Nanoparticles Particles: 1-100 nm Large surface as compared to total amount Mainly Ni, Fe, Au, Pt M. Parlińska, IFJ PAN

Enhanced proton treatment in mouse tumors through proton irradiated nanoradiator effects on metallic nanoparticles Jong-Ki Kim et al., Phys. Med. Biol. 57 (2012) 8309–8323

Enhanced effectiveness of protons + nanoparticles Jong Ki Kim 2012 Phys Med. Biol. 57

Mechanism of dose amplification by gold nanoparticles, AuNP Jong Ki Kim 2012 Phys Med. Biol. 57

Mechanism of dose amplification by gold nanoparticles, AuNP Jong Ki Kim 2012 Phys Med. Biol. 57

Microdosimetry of low-energy photons P.Olko, Ph.D. thesis 1989 Low energy photons can enhanced RBE because of short, densely ionizing electron tracks

Spatial distribution of nanoparticles in biological cells - how does it influence the proton action Yuting Lin et al 2015 Phys. Med. Biol. 60 4149

Irradiation modalities: protons, MV X-rays and kV X-rays Yuting Lin et al 2015 Phys. Med. Biol. 60 4149

Local doses in the vicinity of gold nanoparticles (GNP) Yuting Lin et al 2015 Phys. Med. Biol. 60 4149 50 nm GNP protons For lower GNP diameters dose increases close to the surface

Cell survival after proton irradiation with gold nanoparticles (GNP) Yuting Lin et al 2015 Phys. Med. Biol. 60 4149 For the same weight the smallest GNPs are more effective

Cell survival after irradiation with gold nanoparticles (GNP) Yuting Lin et al 2015 Phys. Med. Biol. 60 4149 If NPs are not introduced in cell nucleus – no effect on survival

Survival for protons, 6 MV X-rays,250 kVp X-rays Yuting Lin et al 2015 Phys. Med. Biol. 60 4149 Protons and MV X-rays show equivalent survival only when the GNPs are in cell nucleus

Future work 1) New biofunctionalised NP 2) Cell radiobiology with NP 3) Radiobiology in animal models 4) Imaging NP transport with MRI 5) Microdosimetry of NP 6) TPS with included NP. modules

Future work 1) New biofunctionalised NP 2) Cell radiobiology with NP 3) Radiobiology in animal models 4) Imaging NP transport with MRI 5) Microdosimetry of NP 6) TPS with included NP. modules Uptake kinetic of the gadolinium based contrast agent in model tumour as assessed by 9.4T DCE MRI study at IFJ PAN [11].

Future work 1) New biofunctionalised NP 2) Cell radiobiology with NP 3) Radiobiology in animal models 4) Imaging NP transport with MRI 5) Microdosimetry of NP 6) TPS with included NP modules Alpha-particle and 3H tracks observed in LiF FNTD developed at IFJ PAN (Bilski & Marczewska, 2017

Future work 1) New biofunctionalised NP 2) Cell radiobiology with NP 3) Radiobiology in animal models 4) Imaging NP transport with MRI 5) Microdosimetry of NP 6) TPS with included NP modules TPS with option for calculation of enhanced RBE/dose due to proton interaction with NP

M. Lekka, M. Parlińska, MPR Waligórski, W. Weglarz Thank you Acknowledgements to: M. Lekka, M. Parlińska, MPR Waligórski, W. Weglarz