Ketamine, but not propofol, anaesthesia is regulated by metabotropic glutamate 5 receptors  Sou J.-H. , Chan M.-H. , Chen H.-H.   British Journal of Anaesthesia  Volume 96, Issue 5, Pages 597-601 (May 2006) DOI: 10.1093/bja/ael046 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 1 Dose-dependent effect of DHPG and CHPG on ketamine-induced anaesthesia. Mice were pretreated with ACSF, DHPG (5 and 50 nmol, i.c.v.) (a) or CHPG (0.5, 2.5 and 5 nmol, i.c.v.) (b) and the duration of LORR was recorded after administration of ketamine (120 mg kg−1, i.p.). All values are expressed as the mean (sem) (n=6). One-way anova: F(2,15)=7.098, P=0.0068 for DHPG; F(3,20)=18.91, P<0.0001 for CHPG; *P<0.05, **P<0.01, ***P<0.001 compared with the vehicle control (Student–Newman–Keuls test). British Journal of Anaesthesia 2006 96, 597-601DOI: (10.1093/bja/ael046) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 2 Dose-dependent effect of CPCCOEt and MPEP on ketamine-induced anaesthesia. Mice were pretreated with ACSF, CPCCOEt (5, 50 and 500 nmol, i.c.v.) (a) or MPEP (50, 100 and 200 nmol, i.c.v.) (b) and the duration of LORR was recorded after administration of ketamine (120 mg kg−1, i.p.). All values are expressed as the mean (sem) (n=6). One-way anova: F(3,20)=2.762, P=0.07 for CPCCOEt; F(3,20)=13.77, P<0.0001 for MPEP. ***P<0.001 compared with the vehicle control (Student–Newman–Keuls test). British Journal of Anaesthesia 2006 96, 597-601DOI: (10.1093/bja/ael046) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 3 Dose-dependent effect of DHPG and CHPG on propofol-induced anaesthesia. Mice were pretreated with ACSF, DHPG (5 and 50 nmol, i.c.v.) (a) or CHPG (5 and 50 nmol, i.c.v.) (b) and the duration of LORR was recorded after administration of propofol (140 mg kg−1, i.p.). All values are expressed as the mean (sem) (n=6). One-way anova: F(2,15)=0.476, P=0.63 for DHPG; F(2,15)=0.727, P=0.499 for CHPG. British Journal of Anaesthesia 2006 96, 597-601DOI: (10.1093/bja/ael046) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 4 Dose-dependent effect of CPCCOEt and MPEP on propofol-induced anaesthesia. Mice were pretreated with ACSF, CPCCOEt (50 and 500 nmol, i.c.v.) (a) or MPEP (50 and 200 nmol, i.c.v.) (b) and the duration of LORR was recorded after administration of propofol (140 mg kg−1, i.p.). All values are expressed as the mean (sem) (n=6). One-way anova: F(2,15)=0.133, P=0.87 for CPCCOEt; F(2,15)=0.542, P=0.59 for MPEP. British Journal of Anaesthesia 2006 96, 597-601DOI: (10.1093/bja/ael046) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions