Effects of haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model B.

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Effects of haemoglobin-based oxygen carrier Hemoglobin glutamer-200 (bovine) on intestinal perfusion and oxygenation in a canine hypovolaemia model B. Driessen, J.S. Jahr, F. Lurie, S.M. Griffey, R.A. Gunther British Journal of Anaesthesia Volume 86, Issue 5, Pages 683-692 (May 2001) DOI: 10.1093/bja/86.5.683 Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 1 Cranial mesenteric arterial (CMA) and venous (CMV) blood flow in anaesthetized dogs at baseline (end of equilibration), 60 min after haemorrhage (end of hypovolaemia) and immediately (Resuscitation I) and 3 h (Resuscitation II) after transfusion of autologous blood (control) and Hemoglobin glutamer-200 (bovine). Values are mean (sem) for six dogs in each group. Significant differences from baseline values: *P<0.05; **P<0.01. British Journal of Anaesthesia 2001 86, 683-692DOI: (10.1093/bja/86.5.683) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 2 Systemic and mesenteric oxygen delivery in anaesthetized dogs at baseline (end of equilibration), 60 min after haemorrhage (end of hypovolaemia), and immediately (Resuscitation I) and 3 h (Resuscitation II) after transfusion of autologous blood (control) or Hemoglobin glutamer-200 (bovine). Values are mean (sem) for six dogs in each group. Significant differences from baseline values: *P<0.05; **P<0.01. Significant differences between control and Hb-200 groups: ##P<0.01. British Journal of Anaesthesia 2001 86, 683-692DOI: (10.1093/bja/86.5.683) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 3 Systemic and mesenteric oxygen extraction ratio in anaesthetized dogs at baseline (end of equilibration), 60 min after haemorrhage (end of hypovolaemia), and immediately (Resuscitation I) and 3 h (Resuscitation II) after transfusion of autologous blood (open circles, control) or Hemoglobin glutamer-200 (bovine) (closed circles). Values are mean (sem) for six dogs in each group. Significant differences from baseline values: *P<0.05; **P<0.01. Significant differences between control and Hb-200 groups: #P<0.05; P<0.01. Significant differences between systemic and mesenteric oxygen extraction: †P<0.05. British Journal of Anaesthesia 2001 86, 683-692DOI: (10.1093/bja/86.5.683) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions