Partial liquid ventilation for acute allograft dysfunction after canine lung transplantation Hideki Itano, MD, Motoi Aoe, MD, Shingo Ichiba, MD, Motohiro.

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Presentation transcript:

Partial liquid ventilation for acute allograft dysfunction after canine lung transplantation Hideki Itano, MD, Motoi Aoe, MD, Shingo Ichiba, MD, Motohiro Yamashita, MD, Hiroshi Date, MD, Akio Andou, MD, Nobuyoshi Shimizu, MD The Annals of Thoracic Surgery Volume 67, Issue 2, Pages 332-339 (February 1999) DOI: 10.1016/S0003-4975(98)01136-9

Fig 1 Arterial oxygen tension (Pao2) and arterial carbon dioxide tension (Paco2) in the two groups: the control group (•) and the partial liquid ventilation (PLV) group (▴); n = 6 dogs in each group. Data are shown as the mean ± standard deviation. The Pao2 in the PLV group was significantly higher than that of the control group after 120 minutes (∗ p < 0.05 versus control; † p < 0.01 versus control). The Paco2 showed no significant difference after 15 minutes. INT = the point of intubation. The Annals of Thoracic Surgery 1999 67, 332-339DOI: (10.1016/S0003-4975(98)01136-9)

Fig 2 Alveolar to arterial gradient for O2 (A-aDO2) and shunt fraction (Qs/Qt) in the two groups: the control group (•) and the PLV group (▴); n = 6 dogs in each group. Data are shown as the mean ± standard deviation. The A-aDO2 in the PLV group was significantly lower than that in the control group after the 120 minutes (∗ p < 0.05 versus control; § p < 0.001 versus control). The Qs/Qt in the PLV group was significantly lower than that in the control group after 180 minutes (∗ p < 0.05 versus control; § p < 0.001 versus control). The Annals of Thoracic Surgery 1999 67, 332-339DOI: (10.1016/S0003-4975(98)01136-9)

Fig 3 Peak airway pressure (peak AwP) in the two groups: the control group (•), and the PLV group (▴); n = 6 dogs in each group. Data are shown as the mean ± standard deviation. After 180 minutes, peak AwP in the PLV group was significantly lower than that in the control group (∗ p < 0.05 versus control). The Annals of Thoracic Surgery 1999 67, 332-339DOI: (10.1016/S0003-4975(98)01136-9)

Fig 4 Mean pulmonary artery pressure (mean PAP) and pulmonary vascular resistance (PVR) in the two groups: the control group (•), and the PLV group (▴); n = 6 dogs in each group. Data are shown as the mean ± standard deviation. After approximately 180 minutes, both mean PAP and PVR in the PLV group were lower than those in the control group, but differences were not significant. The Annals of Thoracic Surgery 1999 67, 332-339DOI: (10.1016/S0003-4975(98)01136-9)

Fig 5 Cardiac output (CO) and mean aortic pressure (mAoP) in the two groups: the control group (•) and the PLV group (▴); n = 6 dogs in each group. Data are shown as the mean ± standard deviation. After 15 minutes, there was no significant difference between the two groups with respect to these parameters. The Annals of Thoracic Surgery 1999 67, 332-339DOI: (10.1016/S0003-4975(98)01136-9)

Fig 6 Myeloperoxidase (MPO) activity in the two groups: n = 6 dogs in each group. Data are shown as the mean ± standard deviation. There was a tendency for lower MPO activity in the PLV group compared with that in the control group. The Annals of Thoracic Surgery 1999 67, 332-339DOI: (10.1016/S0003-4975(98)01136-9)

Fig 7 Specimens from the posterior aspect of the lower lobe of an allograft after the completion of assessment, which represent both groups. Views of the control group, ×40 magnification (A) and ×100 (B), as well as the PLV group, ×40 (C) and ×100 (D) (hematoxylin and eosin stain). Reductions in pulmonary vascular congestion, alveolar hemorrhage, alveolar proteinaceous fluid accumulation, and inflammatory infiltration are noted, and consequently lung architecture is well preserved in the PLV group. The Annals of Thoracic Surgery 1999 67, 332-339DOI: (10.1016/S0003-4975(98)01136-9)