Volume 56, Issue 5, Pages (November 1999)

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Presentation transcript:

Volume 56, Issue 5, Pages 1934-1943 (November 1999) Effects of an amino acid dialysate on leucine metabolism in continuous ambulatory peritoneal dialysis patients Jacques Delarue, M.D., Ph.D., Claude Maingourd, Martine Objois, Michèle Pinault, Richard Cohen, Charles Couet, Fernand Lamisse Kidney International Volume 56, Issue 5, Pages 1934-1943 (November 1999) DOI: 10.1046/j.1523-1755.1999.00723.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Protocol design. Kidney International 1999 56, 1934-1943DOI: (10.1046/j.1523-1755.1999.00723.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Kinetics of plasma glucose (A), nonesterified fatty acids (B), and insulin (C) concentrations after peritoneal delivery of an 1.1% amino acid solution with (▪) or without (□) meal ingestion. Kidney International 1999 56, 1934-1943DOI: (10.1046/j.1523-1755.1999.00723.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Kinetics of respiratory quotient (A), carbohydrate oxidation (B), and lipid oxidation (C) after peritoneal delivery of an 1.1% amino acid solution with (▪) or without (□) meal ingestion. Kidney International 1999 56, 1934-1943DOI: (10.1046/j.1523-1755.1999.00723.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 Kinetics of dialysate (A) and plasma (B) leucine concentrations after peritoneal delivery of an 1.1% amino acid solution with (▪) or without (□) meal ingestion (*P < 0.001). Kidney International 1999 56, 1934-1943DOI: (10.1046/j.1523-1755.1999.00723.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 5 Kinetics of total rate of plasma leucine appearance (Ra; A), exogenous rate of plasma leucine appearance (B), exogenous leucine oxidation (C), and nonoxidative plasma leucine disposal (D) after peritoneal delivery of an 1.1% amino acid solution with (▪) or without (□) meal ingestion (*P < 0.05). Kidney International 1999 56, 1934-1943DOI: (10.1046/j.1523-1755.1999.00723.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 6 Kinetics of the endogenous leucine rate of appearance in plasma (Raendo) relative to the basal value after peritoneal delivery of a 1.1% amino acid solution with (▪) or without (□) meal ingestion (*P < 0.05). Kidney International 1999 56, 1934-1943DOI: (10.1046/j.1523-1755.1999.00723.x) Copyright © 1999 International Society of Nephrology Terms and Conditions