Pretransplant Panel Reactive Antibodies in Human Lung Transplantation: An Analysis of Over 10,000 Patients Ashish S. Shah, MD, Lois Nwakanma, MD, Christopher.

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Pretransplant Panel Reactive Antibodies in Human Lung Transplantation: An Analysis of Over 10,000 Patients Ashish S. Shah, MD, Lois Nwakanma, MD, Christopher Simpkins, MD, Jason Williams, MD, David C. Chang, PhD, John V. Conte, MD The Annals of Thoracic Surgery Volume 85, Issue 6, Pages 1919-1924 (June 2008) DOI: 10.1016/j.athoracsur.2008.02.011 Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Kaplan-Meier estimates of mortality, 1987 through 2005, stratified by four groups of panel reactive antibody (PRA) levels (0%, blue; 1 to 10, red, 11 to 25, green; and > 25, orange). Actuarial survival was calculated for the entire cohort and stratified by PRA level. *Comparison between each group and reference point PRA = 0% by log-rank test. The Annals of Thoracic Surgery 2008 85, 1919-1924DOI: (10.1016/j.athoracsur.2008.02.011) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Kaplan-Meier estimates of mortality, 1987 through 2005, stratified by panel reactive antibody (PRA) level of 25% or less (blue line) or exceeding 25% (orange line). Actuarial survival compares patients with a PRA exceeding 25% vs those with less than 25%. The Annals of Thoracic Surgery 2008 85, 1919-1924DOI: (10.1016/j.athoracsur.2008.02.011) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Kaplan-Meier estimates of mortality, 1987 through 2005 for panel reactive antibody (PRA) exceeding 25%, stratified by type of transplant (TX). Actuarial survival in highly sensitized patients is divided by procedure type. There was no significant difference between single- (SLT, green line) and bilateral-lung transplant (BLT, orange line) recipients. The Annals of Thoracic Surgery 2008 85, 1919-1924DOI: (10.1016/j.athoracsur.2008.02.011) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 (A) Kaplan-Meier estimates of actuarial survival, 1987 through 1997, stratified by panel reactive antibody (PRA) level of 25% or less (blue line) vs exceeding 25% (orange line). Patients with a PRA exceeding 25% have significantly decreased survival compared with patients with a PRA of less than 25%. (B) Kaplan-Meier estimates of actuarial survival in a more modern cohort, 1998 through 2005, stratified by PRA level of less than 25% (blue line) vs exceeding 25% (orange line). Patients with a PRA exceeding 25% did not have a statistically significant survival difference compared with patients with a PRA of less than 25%. The Annals of Thoracic Surgery 2008 85, 1919-1924DOI: (10.1016/j.athoracsur.2008.02.011) Copyright © 2008 The Society of Thoracic Surgeons Terms and Conditions