Orchestrating Twosome and Foursome Chromosome Parties

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Presentation transcript:

Orchestrating Twosome and Foursome Chromosome Parties Paul Kalitsis, K.H. Andy Choo Developmental Cell Volume 17, Issue 3, Pages 305-307 (September 2009) DOI: 10.1016/j.devcel.2009.08.013 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 The Role of CENP-CCnp3 As a Linker Protein in S. pombe during Mitosis and Meiosis I (Ai) During mitosis, sister kinetochores are arranged back-to-back to allow proper bipolar attachment of microtubules. (Aii) During meiosis I, homologous sister kinetochores adopt a side-by-side or fused configuration to allow correct monopolar attachment of microtubules. (Bi) A schematic of the molecular structure of the mitotic kinetochore showing the close association of CENP-CCnp3 with centromeric DNA that is wrapped around the CENP-A-containing nucleosomes. CENP-CCnp3 interacts with Pcs1/Mde4 and CENP-LFta1 subcomplexes to recruit kinetochore/microtubule-binding complexes. The exact position of CENP-TCnp20 that is involved in the alternative pathway of kinetochore assembly is presently unclear and is therefore not shown. (Bii) During meiosis I, CENP-CCnp3 binds to and is essential for Moa1 to keep sister kinetochores mono-oriented. Developmental Cell 2009 17, 305-307DOI: (10.1016/j.devcel.2009.08.013) Copyright © 2009 Elsevier Inc. Terms and Conditions