Effects of short-term simultaneous infusion of dobutamine and terlipressin in patients with septic shock: the DOBUPRESS study† A. Morelli, C. Ertmer,

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Presentation transcript:

Effects of short-term simultaneous infusion of dobutamine and terlipressin in patients with septic shock: the DOBUPRESS study† A. Morelli, C. Ertmer, M. Lange, M. Dünser, S. Rehberg, H. Van Aken, P. Pietropaoli, M. Westphal British Journal of Anaesthesia Volume 100, Issue 4, Pages 494-503 (April 2008) DOI: 10.1093/bja/aen017 Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 1 Study design. MAP, mean arterial pressure; CI, cardiac index. British Journal of Anaesthesia 2008 100, 494-503DOI: (10.1093/bja/aen017) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 2 Systemic haemodynamics of study patients. Data are presented as mean values (sd). BL, baseline; HR, heart rate; CI, cardiac index; SVRI, systemic vascular resistance index; LVSWI, left-ventricular stroke work index; *P<0.05 Group 1 vs Group 2; †P<0.05 Group 1 vs Group 3; ‡P<0.05 Group 2 vs Group 3; §P<0.05 vs BL (in all groups). Baseline data were obtained at the fixed norepinephrine dose of 0.9 μg kg−1 min−1. British Journal of Anaesthesia 2008 100, 494-503DOI: (10.1093/bja/aen017) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 3 Systemic oxygen delivery, oxygen extraction, and mixed-venous oxygen saturation of study patients. Data are presented as mean values (sd). BL, baseline; DO2I, systemic oxygen delivery index; O2-ER, oxygen extraction rate; Svo2, mixed-venous oxygen saturation; *P<0.05 Group 1 vs Group 2; †P<0.05 Group 1 vs Group 3; ‡P<0.05 Group 2 vs Group 3; §P<0.05 vs BL (in all groups). Baseline data were obtained at the fixed norepinephrine dose of 0.9 μg kg−1 min−1. British Journal of Anaesthesia 2008 100, 494-503DOI: (10.1093/bja/aen017) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions

Fig 4 Norepinephrine requirements. Data are presented as mean values (sd). BL, baseline; NE, norepinephrine; *P<0.05 Group 1 vs Group 2; †P<0.05 Group 1 vs Group 3. Baseline data were obtained at the fixed norepinephrine dose of 0.9 μg kg−1 min−1. British Journal of Anaesthesia 2008 100, 494-503DOI: (10.1093/bja/aen017) Copyright © 2008 British Journal of Anaesthesia Terms and Conditions