Volume 60, Issue 3, Pages (September 2001)

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Presentation transcript:

Volume 60, Issue 3, Pages 969-973 (September 2001) Mesangial IgA1 in IgA nephropathy exhibits aberrant O-glycosylation: Observations in three patients Alice C. Allen, Elaine M. Bailey, Paul E.C. Brenchley, Katharine S. Buck, Jonathan Barratt, John Feehally Kidney International Volume 60, Issue 3, Pages 969-973 (September 2001) DOI: 10.1046/j.1523-1755.2001.060003969.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Binding of Vicia villosa (VV) and Helix aspersa (HA) lectins to serum and mesangial IgA1. Binding of VV (A) and HA (B) lectins to serum IgA1 from IgAN and controls (○); serum IgA1 from patients A, B, and C (♦); and IgA1 eluted from the glomeruli of patients A, B, and C (★). In all of the experiments, both the VV and HA lectin binding of serum IgA1 from patients with IgAN was significantly higher than that of controls (as indicated by the P values on each graph), and the lectin binding to mesangial IgA1 was higher than to serum IgA1 of the same subject. Note the ratios of A492lectin:A492IgA1 were derived from raw data and are arbitrary values that vary between assay runs. Therefore, the ordinate scales differ between the experiments and direct comparisons between the different experiments should not be made. Kidney International 2001 60, 969-973DOI: (10.1046/j.1523-1755.2001.060003969.x) Copyright © 2001 International Society of Nephrology Terms and Conditions