Dose-response of compression therapy for chronic venous edema—higher pressures are associated with greater volume reduction: Two randomized clinical studies

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Presentation transcript:

Dose-response of compression therapy for chronic venous edema—higher pressures are associated with greater volume reduction: Two randomized clinical studies Wolfgang Vanscheidt, MD, Alexandra Ukat, MD, Hugo Partsch, MD Journal of Vascular Surgery Volume 49, Issue 2, Pages 395-402.e1 (February 2009) DOI: 10.1016/j.jvs.2008.08.070 Copyright © 2009 The Society for Vascular Surgery Terms and Conditions

Fig 1 Device comfort ratings by pneumatic pressure profile. Most subjects reported being comfortable or very comfortable with each pressure profile, and no subject reported being very uncomfortable. Device comfort ratings were not applicable for the periods with no treatment. Pressures refer to the pressure administered at the gaiter. Twelve subjects were treated with each sustained pneumatic compression (SPC) profile for 6 hours, with at least 48 hours between each profile. Sixteen subjects were treated with each intermittent pneumatic compression (IPC) profile for two hours, with at least 46 hours between each profile. Journal of Vascular Surgery 2009 49, 395-402.e1DOI: (10.1016/j.jvs.2008.08.070) Copyright © 2009 The Society for Vascular Surgery Terms and Conditions

Fig 2 A, Mean (SEM) absolute change in leg volume from baseline for each sustained pneumatic compression (SPC) profile and least-squares mean for the difference between the treated and untreated legs. B, Mean (SEM) relative reduction in leg volume with SPC, treated leg vs untreated leg. Pressures for each graduated and nongraduated profile refer to the pressure administered at the gaiter. Treatment with SPC was associated with dose-dependent mean reductions of leg volume from the start to the end of each six-hour observation/treatment period. Twelve subjects were treated with each profile for six hours, with at least 48 hours between each profile. *P value based on least-squares mean, pairwise comparison to no compression. Journal of Vascular Surgery 2009 49, 395-402.e1DOI: (10.1016/j.jvs.2008.08.070) Copyright © 2009 The Society for Vascular Surgery Terms and Conditions

Fig 3 A, Mean (SEM) absolute change in leg volume from baseline for each intermittent pneumatic compression (IPC) profile and least-squares mean for the difference between the treated and untreated legs. B, Mean (SEM) relative reduction in leg volume with IPC, treated leg vs untreated leg. Reported reduction or increase for each profile is the least-squares mean for the difference between the treated and untreated legs. Treatment with IPC was associated with dose-dependent mean (SEM) reductions of leg volume from the start to the end of each treatment period. Sixteen subjects were treated with each profile for 2 hours, with at least 46 hours between each profile. *P value based on least-squares mean, pairwise comparison to no compression. Journal of Vascular Surgery 2009 49, 395-402.e1DOI: (10.1016/j.jvs.2008.08.070) Copyright © 2009 The Society for Vascular Surgery Terms and Conditions