Dissecting Modulatory Effects of Visual Attention in Primate Lateral Prefrontal Cortex Using Signal Detection Theory Julio Martinez-Trujillo, Roberto.

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Presentation transcript:

Dissecting Modulatory Effects of Visual Attention in Primate Lateral Prefrontal Cortex Using Signal Detection Theory Julio Martinez-Trujillo, Roberto Adamo Gulli Neuron Volume 97, Issue 6, Pages 1208-1210 (March 2018) DOI: 10.1016/j.neuron.2018.03.012 Copyright © 2018 Terms and Conditions

Figure 1 Modulation of PFC Neuronal Activity by Changes in Sensitivity and Bias (A) Noisy distributions of signal are recorded in trials with a change in the stimulus (purple) or no change in the stimulus (cyan). The observer’s sensitivity describes how much of each distribution overlaps. The observer’s decision criterion (dotted line) marks the minimum signal measurement at which they report a change. Therefore, each report has one of four possible outcomes: hit, miss, correct rejection, or false alarm. (B) Changes in sensitivity (d’) reduce the overlap between distributions. This changes hit rates and correct rejection rates when the criterion is kept at the isopleth. (C) Changes in criterion (c) affect the observer’s report independently without changes in signal distributions. (D) A schematic of the effect of d’ or c changes on hit rates and correct rejection rates. (E) Luo and Maunsell (2018) use a change detection paradigm with four possible trial outcomes at the change detection test phase. Incentivizing monkeys to favor hits versus correct rejections in some sessions, and hits and correct rejections in other sessions, allowed the authors to determine the effect of each on neuronal activity in lateral prefrontal cortex (LPFC) (reproduced from Luo and Maunsell, 2018 with permission). (F) Activity of LFPC neurons was modulated by changes in d’ and changes in c (reproduced from Luo and Maunsell, 2018 with permission). The magnitude of each effect was correlated across individual neurons. In contrast, previous studies showed only d’ affects neuronal activity in V4, while c primarily affects neuronal activity in the superior colliculus. Neuron 2018 97, 1208-1210DOI: (10.1016/j.neuron.2018.03.012) Copyright © 2018 Terms and Conditions