Treatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen.

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Presentation transcript:

Treatment of metabolic acidosis in patients with stage 3 chronic kidney disease with fruits and vegetables or oral bicarbonate reduces urine angiotensinogen and preserves glomerular filtration rate Nimrit Goraya, Jan Simoni, Chan-Hee Jo, Donald E. Wesson Kidney International Volume 86, Issue 5, Pages 1031-1038 (November 2014) DOI: 10.1038/ki.2014.83 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Box plots of plasma total CO2 (TCO2) (left) and 8-hour urine net acid excretion (8h NAE) (right) in chronic kidney disease (CKD) stage 3 individuals at baseline and 3-year follow-up. Usual Care, individuals without additional dietary intervention; HCO3, individuals given oral NaHCO3 at 0.3meq/kg lean bw/day; F+V=subjects given fruits and vegetables in amounts designed to reduce dietary potential renal acid load by half. *P<0.05 vs. respective baseline;+P<0.05 vs. respective Usual Care. Kidney International 2014 86, 1031-1038DOI: (10.1038/ki.2014.83) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 2 Boxplots of change of urine albumin (mg)-to-creatinine (g) ratio (Ualb) (left), N-acetyl-β-D-glucosaminidase (U)-to-creatinine (g) ratio (UNAG), and angiotensinogen (μg)-to creatinine (g) ratio (UATG) for the three groups of chronic kidney disease (CKD) individuals with eGFR 30–59ml/min per 1.73m2 at baseline and 3-year follow-up. *P<0.05 vs. respective baseline;+P<0.05 vs. respective Usual Care. Kidney International 2014 86, 1031-1038DOI: (10.1038/ki.2014.83) Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 3 Error bars (mean±s.e.) of plasma creatinine-calculated estimated GFR (crGFR) (left) and plasma cystatin C–calculated estimated GFR (cysGFR) (right) across four time points including baseline and 3 years’ follow-up. *P<0.05 vs. Usual Care at 2 year;+P<0.05 vs. Usual Care at 3-year follow-up. Kidney International 2014 86, 1031-1038DOI: (10.1038/ki.2014.83) Copyright © 2014 International Society of Nephrology Terms and Conditions